Meytal Landau

PostDoctoral Research

Meytal picture

My current position (starting September 2012):

Assistant Professor at the Faculty of Biology,
Technion - Israel institute of technology, Haifa, Israel

Meytal Landau's Lab

2007-2012 - I was a postdoctoral scholar with Prof. David Eisenberg at UCLA, Los Angeles, USA.

2002-2007 - I was a doctoral student with Prof. Nir Ben-Tal at Tel-Aviv University, Israel.

My Curriculum Vitae

My Structures - Towards a Pharmacophore for Amyloid

Publications by Subject:

Manuscripts Related to My Doctoral Thesis
Manuscripts Related to My Postdoctoral Research
Manuscripts that Stem from Collaborations with Other Research Groups
A Book Chapter Related to My Master Thesis

Some of my crystal trays
Meytal picture

Professional links:

My PhD Thesis


    Manuscripts Related to My Doctoral Thesis

  1. M. Landau, S.J. Fleishman and N. Ben-Tal. A Putative mechanism for down-regulation of the catalytic activity of the EGF receptor via direct contact between its kinase and C-terminal domains. Structure 12: 2265-75, 2004.
  2. M. Landau, I. Mayrose, Y. Rosenberg, F. Glaser, E. Martz, T. Pupko and N. Ben-Tal. ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures. Nucleic Acids Res 33: W299-W302, 2005.
  3. M. Landau, K. Hertz, E. Padan and N. Ben-Tal. Model structure of the Na+/H+ exchanger 1 (NHE1) of the human heart: functional and clinical implications. J Biol Chem. 282(52):37854-63; 2007.
  4. M. Landau and N. Ben-Tal. Dynamic Equilibrium between Multiple Active and Inactive Conformations Explains Regulation and Oncogenic Mutations in ErbB Receptors. Biochim Biophys Acta. Reviews on cancer 1785(1):12-31; 2008.
  5. M. Schushan, M. Landau, E. Padan and N. Ben-Tal (2011). Two conflicting NHE1 model-structures: Compatibility with experimental data and implications for the transport mechanism. J. Biol. Chem. 286, le9; 2011.

  6. Manuscripts related to my Postdoctoral Research

  7. J.W. Wiltzius*, M. Landau*, R. Nelson*, M.R. Sawaya*, M.I. Apostol, L. Goldschmidt, A.B. Soriaga, D.Cascio, K. Rajashankar and D. Eisenberg. Molecular mechanisms for protein-encoded inheritance. Nat. Struct. Mol. Biol. 16(9) 973-8; 2009. *Authors contributed equally
  8. A. Laganowsky, J.L.P. Benesch M. Landau, L. Ding, M.R. Sawaya, D. Cascio, Q. Huang, C.V. Robinson, J. Horwitz, and D. Eisenberg. Crystal structures of truncated α and αB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Prot. Sci. 19(5):1031-43; 2010.
  9. M. Landau, M.R. Sawaya, K.F. Faull, A. Laganowsky, L. Jiang, S.A. Sievers, J. Liu, J.R. Barrio and D. Eisenberg. Towards a Pharmacophore for Amyloid. PLoS Biology 9(6): e1001080; 2011.
  10. JP. Colletier*, A. Laganowsky*, M. Landau*, M. Zhao*, A.B. Soriaga*, L. Goldschmidt, D. Cascio, M.R. Sawaya, and D. Eisenberg. Molecular Basis for Amyloid-β Polymorphism. PNAS 108(41):16938-43; 2011. *Authors contributed equally
  11. A. Laganowsky, C. Lui, M.R. Sawaya, J.P. Whitelegge, J. Park, M. Zhao, A. Pensalfini, A.B. Soriaga, M. Landau, P.K. Teng, D. Cascio, C. Glabe, D. Eisenberg. Atomic View of a Toxic Amyloid Small Oligomer. Science 335(6073):1228-31; 2012.

  12. Manuscripts that Stem from Collaborations with Other Research Groups

    In these publications I used bioinformatics tools to investigate structure-function relationships and to suggest the molecular effects of disease-causing mutations.

  13. N. Rosenberg, M. Landau, J. Luboshitz, G. Rechavi and U. Seligsohn. A novel PHE171CYS mutation in integrin αIIb causes Glanzmann Thrombasthenia by abrogating αIIbβ3 complex formation. J Thromb Haemost 2: 1167-1175, 2004.
  14. O. Ashur-Fabian, A. Avivi, L. Trakhtenbrot, K. Adamsky, M. Cohen, G. Kajakaro, A. Joel, N. Amariglio, E. Nevo and G. Rechavi. Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation. Proc Natl Acad Sci USA 101: 12236-12241, 2004.
  15. A. Vysokovsky, R. Saxema, M. Landau, A. Zivelin, R. Eskaraev, N. Rosenberg, U. Seligsohn and A. Inbal. Seven novel mutations in Factor XIII A-subunit gene causing hereditary Factor XIII deficiency in 10 unrelated families. J Thromb Haemost 2: 1790-1797, 2004.
  16. A. Zivelin, T. Ogawa, S. Bulvik, M. Landau, J.R. Toomey, J. Lane, U. Seligsohn and D. Gailani. Severe factor XI deficiency caused by a Gly555 to Glu mutation (factor XI-Glu555): a cross-reactive material positive variant defective in factor IX activation. J Thromb Haemost 2: 1782-1789, 2004.
  17. Y. Fromovich-Amit, A. Zivelin, N. Rosenberg, H. Tamary, M. Landau and U. Seligsohn. Characterization of mutations causing factor VII deficiency in 61 unrelated Israeli patients. J Thromb Haemost 2:1774-1781, 2004.
  18. M. Mark-Danieli, N. Laham, M. Kenan-Eichler, A. Castiel, D. Melamed, M. Landau, N.M. Bouvier, M.J. Evans and E. Bacharach. Single point mutations in the zinc finger motifs of the human immunodeficiency virus type 1 nucleocapsid alter RNA binding specificities of the gag protein and enhance packaging and infectivity. J Virol 79: 7756-67, 2005.
  19. Y. Fromovich-Amit, A. Zivelin, N. Rosenberg, M. Landau, R. Jean-Philippe and U. Seligsohn. Of four mutations in the factor VII gene in Tunisian patients, one novel mutation (Ser339Phe) in three unrelated families abrogates factor X activation. Blood Coagul Fibrinolysis 16: 369-374, 2005.
  20. N. Rosenberg, H. Hauschner, H. Peretz, R. Mor-Cohen, M. Landau, B. Shenkman, G. Kenet, B.S. Coller, A. A. Awidi and U. Seligsohn. A 13bp Deletion in αIIb Gene is a Founder Mutation that Predominates in Palestinian Arab Patients with Glanzmann Thrombasthenia. J Thromb Haemost 3: 2764-72, 2005.
  21. H. Peretz, N. Rosenberg, M. Landau, S. Usher, E.J.R. Nelson, R. Mor-Cohen, D.L. French, B.W. Mitchell, S.C. Nair, M. Chandy, B.S. Coller, A. Srivastava and U. Seligsohn. Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of αIIbβ3 integrin (ITGA2B, ITGB3). Human Mutation 27:359-369, 2006.
  22. N. Rosenberg, S. Lalezari, M. Landau, B. Shenkman, U. Seligsohn and S. Izraeli. Trp207Gly in platelet glycoprotein Ibα is a novel mutation which disrupts the connection between the leucine-rich repeat domain and the disulfide loop structure and causes Bernard-Soulier syndrome. J Thromb Haemost 5(2):378-86; 2006.
  23. M. Zucker, A. Zivelin, M. Landau, O. Salomon, G. Kenet, F. Bauduer, M. Samama, J. Conard, H. Denninger, A.B. Hani, M. Berruyer, D. Feinstein, U. Seligsohn. Characterization of seven novel mutations causing FXI deficiency. Haematologica, 92(10):1375-80; 2007.
  24. C. Bozzao, V. Rimoldi, R. Asselta, M. Landau, R. Ghiotto, M.L. Tenchini, R. De Cristofaro, G. Castaman and S. Duga. A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency. FEBS J. 274: 6128-6138; 2007.
  25. R. Mor-Cohen, N. Rosenberg, H. Peretz, M. Landau, B.S. Coller, A. Awidi, U. Seligsohn. Disulfide bond disruption by a β3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active αIIbβ3. J Thromb Haemost. 98(6):1257-65; 2007
  26. R. Mor-Cohen, N. Rosenberg, M. Landau, J. Lahav and U. Seligsohn. Specific cysteines in β3 are involved in disulfide bond exchange-dependent and -independent activation of αIIbβ3. J Biol Chem. 283(28):19235-44; 2008.
  27. M. Zucker, A. Zivelin, M. Landau, N. Rosenberg and U. Seligsohn. Three residues at the interface of factor XI monomers augment covalent dimerization of factor XI. J Thromb Haemost. 7(6):970-5; 2009.
  28. H. Hauschner, M. Landau, U. Seligsohn, and N. Rosenberg. A unique interaction between αIIb and β3 in the head region is essential for outside-in signaling related functions of αIIbβ3 integrin. Blood 115(22):4542-50; 2010.
  29. M. Landau and N. Rosenberg. Molecular Insight into Human Platelet Antigens: Structural and Evolutionary Conservation Analyses offer New Perspective to Immunogenic Disorders. Transfusion 51(3):558-69; 2010.
  30. R. Mor-Cohen, N. Rosenberg, Y. Einav, E. Zelzion, M. Landau, W. Mansour, Y. Averbukh and U. Seligsohn. Unique disulfide bonds in the epidermal growth factor (EGF) domains of β3 affect the structure and function of αIIbβ3 and αvβ3 integrins in a different manner. J Biol Chem 16;287(12):8879-91; 2012.
  31. R. Loewenthal, N. Rosenberg, R. Kalt, R. Dardik, M. Landau, V. Yahalom, O. Avishai, O. Frenkel, E. Gazit, D.M. Steinberg, S. Lipitz, O. Salomon. Compound heterozygosity of HLA-DRB3*01:01 and HLA-DRB4*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia. Transfusion 2012 Jun 7 [Epub ahead of print].

  32. A Book Chapter Related to my Master Thesis

  33. M. Landau and N. Zisapel. The low affinity binding of melatonin to calmodulin: use of computational methods to explain its physiological relevance. Melatonin: from molecules to therapy, S.R. Pandi-Perumal and D.P. Cardinali. Hauppauge, NY: Nova Science Publishers, Inc.; 2006.