Sequence Analysis Example

Example: aligning two sequences
Algorithm: Needleman, Wunsch, and Sellers (1970)
- J. Mol. Biol. 48:443-453
Method
- Fill a comparitive matrix with scores
  - Matches = +1
  - Mismatches = 0
  - Gaps = -1
  - Add path score
    - Highest score to the left in the previous row
      or
    - Highest score below in the previous column
- Find highest mathematical score between the two sequences

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