Welcome to Michael R. Sawaya's Home Page

My research involves X-ray crystallographic studies of macromolecular assemblies and enzymes involved in DNA metabolism, such as helicase/primase, dihydrofolate reductase (DHFR) and DNA polymerase beta (polB). Past projects include construction of a crystallographic movie of DHFR, depicting loop and subdomain conformational movements during one turnover of substrate. I have also written a web server for treating anisotropy in X-ray crystallographic data sets. I work at the UCLA-DOE Molecular Biology Institute.


 
Crystallographic Tutorials - Software Tutorials to Aid You in Determining Your Crystal Structure
 

 Crystallographic Resources

M230D Lab Course Materials - Structural Molecular Biology Laboratory (Chem M230D)

Diffraction Anisotropy Server Scaling and Ellipsoidal truncaction of anisotropic diffraction data

Table 1 Server Automatically generate a table of data and refinement statistics from scalepack and Refmac5 output.

UCLA Crystallographic Servers A variety of automated servers for analyzing crystal structure and data

Cross-ß Crystal Structure Library Access coordinates and interactive Chime illustrations of cross-beta fibrils.

Amyloid Atlas 2020  Structures illustrated from PDB.

Amyloid Models  Speculative models before 2015 .
 

DHFR the Movie Movie based on 30 crystal structures of E.coli DHFR.

 

Polymerase ß the Movie! Movie based on 3 crystal structures of polymase beta.

 
Self Rotation Function Server Calculate and display the self rotation function for your data set.
Matthews Probability Calculator Estimate the number of molecules in the asymmetric unit.
 

Protparam Calculate molecular weight from amino acid sequence. 

NIST*LATTICE Obtain matrices to convert between different lattices. 

References

Fun Links

Meanwhile, here is a musical score to enhance your viewing enjoyment.

If you have any comments about my movie, please click on my email Michael R. Sawaya (sawaya@mbi.ucla.edu). A screen should pop up and there will be buttons for send and cancel.

 

Previously a member of the following laboratories

Back to Kraut Research Group homepage and see other Kraut Group Members.
Back to Ellenberger Group.

 


Michael R. Sawaya
Research Faculty, UCLA Technology Center, Eisenberg, Yeates, Dickerson, Bowie Labs

Questions, comments, or suggestions regarding this page should go to: sawaya@mbi.ucla.edu