Amyloid Atlas 2023Amyloid Atlas 2023

Amyloid Fibril structures illustrated by Michael Sawaya. Supported by National Institute on Aging. To see high resolution images of the amyloid fibril, click on thumbnail images. This page was last updated on January 25, 2023. We have 233 amyloid fibrils listed. See our accompanying review: The expanding amyloid family: Structure, stability, function, and pathogenesis, Cell, Vol 184, Issue 19, Sept. 16, 2021, pp. 4857-4873. Make your own amyloid illustrations automatically with Amyloid Illustrator.

Protein
Fibril Origins
Residues Ordered
Method
Resol- ution (Å)
Polarity Map
Energy Map
PDB ID
Reference
α-synuclein

Recombinant

43-83

cryoEM

3.6

6cu8

Li et al., 2018

α-synuclein wt

Recombinant

43-97

ssNMR

N/A

2n0a

Tuttle et al., 2016

α-synuclein Type 3 Filaments

Recombinant, seeded from Multiple System Atrophy Case 5

36-99

cryoEM

3.18

7nck

Lövestam et al., 2021

α-synuclein H50Q

Recombinant

36-99

cryoEM

3.3

6peo

Boyer et al., 2019

α-synuclein H50Q

Recombinant

36-99

cryoEM

3.6

6pes

Boyer et al., 2019

α-synuclein A53T

Recombinant

37-99

cryoEM

3.5

6lrq

Sun et al., 2020

α-synuclein N-acetylated, 1-103

Recombinant

37-96

cryoEM

3.4

6osm

Ni et al., 2019

α-synuclein

Recombinant, human, complex with ligand F0502B

37-97

cryoEM

2.6

7wmm

Tao et al., 2023

α-synuclein rod polymorph

Recombinant, human

38-97

cryoEM

3.5

6cu7

Li et al., 2018

α-synuclein N-acetylated, 1-122

Recombinant, human

39-97

cryoEM

3.0

6osl

Ni et al., 2019

α-synuclein N-acetylated, 1-140

Recombinant, human

37-97

cryoEM

2.8

6osj

Ni et al., 2019

α-synuclein N-acetylated, 1-140,

Recombinant, human

37-99

cryoEM

3.07

6a6b

Li et al., 2018

α-synuclein (1-121)

Recombinant

38-95

cryoEM

3.4

6h6b

Guerrero-Ferreira et al., 2018

α-synuclein

Recombinant, human, heparin-remodeled

37-94

cryoEM

3.50

7v4d

Fan et al., 2022

α-synuclein

Recombinant, human, seeded from a Parkinson's Disease patient, postmortem, filament type 4

36-95

cryoEM

3.40

7v49

Fan et al., 2022

α-synuclein

Recombinant, human, seeded from a Parkinson's Disease patient, postmortem, minor polymorph

36-95

cryoEM

3.40

8h05

Fan et al., 2022

α-synuclein

Human, extracted from Multiple System Atrophy Case 2, Type II-2 fibril

14-99

cryoEM

3.1

6xyq

Schweighauser et al., 2020

α-synuclein

Human, extracted from Multiple System Atrophy brain, Case 2, Type II-1 fibril

14-99

cryoEM

3.3

6xyp

Schweighauser et al., 2020

α-synuclein

Human, extracted from Multiple System Atrophy brain, Case 1, Type I fibril

14-99

cryoEM

2.6

6xyo

Schweighauser et al., 2020

α-synuclein E46K

Recombinant

45-99

cryoEM

3.37

6l4s

Zhao et al., 2020a

α-synuclein wild type

Recombinant, seeded with E46K hereditary mutation

46-96

cryoEM

3.8

7c1d

Long et al., 2021

α-synuclein G51D hereditary mutation

Recombinant

50-98

cryoEM

3.02

7e0f

Sun et al., 2021

α-synuclein

Recombinant, human, recombinant, heparin-induced, polymorph 4

37-98

cryoEM

3.30

7v4c

Fan et al., 2022

α-synuclein

Recombinant, human, recombinant, heparin-induced, polymorph 1

14-25, 32-99

cryoEM

3.20

7v4a

Fan et al., 2022

α-synuclein polymorph 2b

Recombinant

14-25, 36-96

cryoEM

3.4

6sst

Guerrero-Ferreira et al., 2019

α-synuclein polymorph 2b

Recombinant

9-24, 35-93

cryoEM

3.5

6rtb

Guerrero-Ferreira et al., 2019

α-synuclein Type 2A Filaments

Recombinant, seeded from Multiple System Atrophy Case 2

37-97

cryoEM

3.43

7ncg

Lövestam et al., 2021

α-synuclein Type 2B Filaments

Recombinant, seeded from Multiple System Atrophy Case 1

14-25, 36-91

cryoEM

3.55

7nci

Lövestam et al., 2021

α-synuclein Type 2AB Filaments

Recombinant, seeded from Multiple System Atrophy Case 1

37-97

cryoEM

4.23

7ncj

Lövestam et al., 2021

α-synuclein

Recombinant, seeded from Multiple System Atrophy

36-93

cryoEM

3.02

7ozh

Frieg et al., 2022

α-synuclein

Recombinant, human, seeded from a Parkinson's Disease patient, mid-to-late stage 1, major polymorph

36-97

cryoEM

3.00

7xo1

Fan et al., 2022

α-synuclein

Recombinant, human, seeded from a Parkinson's Disease patient, mid-to-late stage 4, filament type 1C

36-98

cryoEM

2.60

7xo3

Fan et al., 2022

α-synuclein

Recombinant, human, seeded from a Parkinson's Disease patient, preclinical, filament type 1A

36-96

cryoEM

2.80

7v47

Fan et al., 2022

α-synuclein

Recombinant, human, seeded from Parkinson's Disease patient, preclinical, major polymorph

36-96

cryoEM

2.80

8h03

Fan et al., 2022

α-synuclein

Recombinant, human, seeded from a Parkinson's Disease patient, postmortem, filament type 1D

36-98

cryoEM

3.00

7v48

Fan et al., 2022

α-synuclein

Recombinant, human, seeded from a Parkinson's Disease patient postmortem, major polymorph

36-98

cryoEM

3.00

8h04

Fan et al., 2022

α-synuclein

Recombinant, human, recombinant, heparin-induced, polymorph 3

14-25, 32-99

cryoEM

3.10

7v4b

Fan et al., 2022

α-synuclein polymorph 2a

Recombinant

14-25, 36-95

cryoEM

3.1

6rt0

Guerrero-Ferreira et al., 2019

α-synuclein polymorph 2a

Recombinant

14-25, 36-96

cryoEM

3.0

6ssx

Guerrero-Ferreira et al., 2019

α-synuclein E46K

Recombinant

36-98

cryoEM

2.5

6ufr

Boyer et al., 2020

α-synuclein Type 1A Filaments

Recombinant, seeded from Multiple System Atrophy Case 2

37-97

cryoEM

3.47

7nca

Lövestam et al., 2021

α-synuclein

Recombinant, human, seeded from a Parkinson's Disease patient, mid-to-late stage 1, minor polymorph

36-97

cryoEM

3.00

7xo0

Fan et al., 2022

α-synuclein

Recombinant, human, seeded from a Parkinson's Disease patient, mid-to-late stage 4, minor polymorph

36-97

cryoEM

3.00

7xo2

Fan et al., 2022

α-synuclein Type 1B Filaments

Recombinant, seeded from Multiple System Atrophy Case 1

14-25, 36-91

cryoEM

3.84

7nch

Lövestam et al., 2021

α-synuclein

Recombinant, seeded from brain of Parkinson's Disease Patient

14-25,36-96

cryoEM

3.30

7ozg

Frieg et al., 2022

α-synuclein, human

Recombinant, Lipidic, Polymorph L2B

14-24,33-96

cryoEM

3.05

8ads

Frieg et al., 2022b

α-synuclein, human

Recombinant, Lipidic, Polymorph L1A

1-99

cryoEM

3.24

8adu

Frieg et al., 2022b

α-synuclein, human

Recombinant, Lipidic, Polymorph L1B

1-99

cryoEM

2.98

8adv

Frieg et al., 2022b

α-synuclein, human

Recombinant, Lipidic, Polymorph L1C

1-99

cryoEM

2.95

8adw

Frieg et al., 2022b

α-synuclein, human

Recombinant, Lipidic, Polymorph L3A

14-19,33-97

cryoEM

2.76

8aex

Frieg et al., 2022b

α-synuclein

human, recombinant, heparin-remodeled, lipidic polymorph L2A

14-24, 33-96

cryoEM

3.22

8a4l

Frieg et al., 2022

α-synuclein

Human, extracted from Parkinson's Disease Dementia patient brain; identical fold as Parkinson's Disease and Dementia with Lewy bodies

14-22, 31-100

cryoEM

2.16

8a9l

Yang et al., 2022

α-synuclein phospho-Y39 twist-dimer

Semisynthetic

1-100

cryoEM

3.22

6l1t

Zhao et al., 2020b

α-synuclein phospho-Y39 twist-trimer

Semisynthetic

1-100

cryoEM

3.37

6l1u

Zhao et al., 2020b

α-synuclein N-terminal Truncation 41-140

Recombinant

46-96

cryoEM

3.2

7lc9

McGlinchey et al., 2021

α-synuclein Filaments

Recombinant, formed in the presence of Tau

37-79

cryoEM

4.00

7l7h

Hojjatian et al., 2021

Amyloid-β(1-42)

Recombinant

17-42

ssNMR

N/A

2beg

Lührs et al., 2005

Amyloid-β(1-40) Iowa Mutation D23N

Recombinant

15-40

ssNMR

N/A

2lnq

Qiang et al., 2012

Amyloid-β(1-40) (+)stagger

Recombinant

9-40

ssNMR

N/A

2lmn

Paravastu et al., 2008

Amyloid-β(1-40) (-)stagger

Recombinant

9-40

ssNMR

N/A

2lmo

Paravastu et al., 2008

Amyloid-β(1-40) (+)stagger

Recombinant

9-40

ssNMR

N/A

2lmp

Paravastu et al., 2008

Amyloid-β(1-40) (-)stagger

Recombinant

9-40

ssNMR

N/A

2lmq

Paravastu et al., 2008

Amyloid-β(1-40) Iowa Mutation D23N

Recombinant

15-40

ssNMR

N/A

2mpz

Sgourakis et al., 2015

Amyloid-β(1-40)

Recombinant, seeded from brain of a human with Alzheimers Disease

1-40

ssNMR

N/A

2m4j

Lu et al., 2013

Amyloid-β(1-42)

Recombinant

16-40

CryoEM

5.0

5aef

Schmidt et al., 2015

Amyloid-β(20-34)(L-isoAsp23)

Synthetic

20-34

MicroED

1.1

6nb9

Warmack et al., 2019

Amyloid-β(20-34)

Synthetic

20-34

MicroED

1.1

6oiz

Warmack et al., 2019

Amyloid-β(1-42)

Recombinant

11-42

ssNMR

N/A

2mxu

Xiao et al., 2015

Amyloid-β(1-42)

Recombinant

14-42

ssNMR

N/A

5kk3

Colvin et al., 2016

Amyloid-β(1-42)

Recombinant

14-42

ssNMR

N/A

2nao

Wälti et al., 2016

Amyloid-β(1-40) E22Δ Osaka mutation

Recombinant

1-40

ssNMR

N/A

2mvx

Schütz et al., 2015

Amyloid-β(1-42)

Recombinant

1-42

cryoEM

4.0

5oqv

Gremer et al., 2017

Amyloid-β

Extracted from brain of a human with Alzheimers Disease (meningeal tissue)

1-40

cryoEM

4.4

6shs

Kollmer et al., 2019

Amyloid-β(1-40)

Seeded with fibrils extracted from brain of a human with Alzheimers Disease (cortical tissue)

10-40

cryoEM

2.77

6w0o

Ghosh et al., 2021

Amyloid-β(1-40)

Recombinant

11-40

ssNMR

N/A

6ti5

Cerofolini et al., 2020

Amyloid-β(1-40 and 1-42 co-fibril)

Human, recombinant

11-40, 11-42

ssNMR

N/A

6ti6

Cerofolini et al., 2020

Amyloid-β(1-42), human

Extracted from the brain of a patient with Alzheimers Disease, type I filaments

9-42

cryoEM

2.5

7q4b

Yang et al., 2022

Amyloid-β(1-42), human

Aqueous extracts from the brain of a patient with Alzheimers Disease, type I filaments

9-42

cryoEM

2.9

8azs

Stern et al., 2022

Amyloid-β(1-42), human

Extracted from the brain of a patient with Alzheimers Disease, type II filaments

12-42

cryoEM

2.8

7q4m

Yang et al., 2022

Amyloid-β(1-42), human

Aqueous extracts from the brain of a patient with Alzheimers Disease, type II filaments

12-42

cryoEM

3.7

8azt

Stern et al., 2022

Amyloid-β(1-42)

Synthetic, glycosylated at Tyr10

6-42

cryoEM

3.10

7f29

Liu et al., 2021

Antimicrobial peptide uperin 3.5

Synthetic, Mjobergs toadlet

1-17

cryoEM

3.0

7qv5

Bücker et al., 2022

Antimicrobial peptide aurein 3.3

Synthetic, blue-thighed tree frog

1-17

cryoEM

3.5

7qv6

Bücker et al., 2022

β-2-microglobulin

Recombinant

22-85

cryoEM

3.9

6gk3

Iadanza et al., 2018

β-2-microglobulin

Recombinant

20-41

ssNMR

N/A

2e8d

Iwata et al., 2006

β-endorphin

Recombinant

1-31

ssNMR

N/A

6tub

Seuring et al., 2020

CA150 WW2 Domain

Recombinant

3-33

ssNMR

N/A

2nnt

Ferguson et al., 2006

FUS LC Domain

Recombinant

37-97

ssNMR

N/A

5w3n

Murray et al., 2017

FUS LC Domain

Recombinant

112-150

cryoEM

2.62

6xfm

Lee et al., 2021

FUS LC Domain

Recombinant

34-124

cryoEM

2.9

7vqq

Sun et al., 2021

Glucagon

Synthetic

1-29

ssNMR

N/A

6nzn

Gelenter et al., 2019

HET-s (218-289)

Recombinant

224-283

ssNMR

N/A

2rnm

Wasmer et al., 2008

hnRNPA1

Recombinant

251-295

cryoEM

2.8

7bx7

Sun et al., 2020

hnRNPA2

Recombinant

251-295

cryoEM

3.1

6wqk

Lu et al., 2020

Islet Amyloid Polypeptide (IAPP), human, SUMO-tagged

Recombinant

14-37

cryoEM

3.7

6vw2

Cao et al., 2020

Islet Amyloid Polypeptide (IAPP), amidated, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 2

6-37

cryoEM

3.9

7m62

Cao et al., 2021

Islet Amyloid Polypeptide (IAPP), amidated, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 3

13-37

cryoEM

4.0

7m64

Cao et al., 2021

Islet Amyloid Polypeptide (IAPP) C-term amidated

Human, synthetic

13-37

cryoEM

4.2

6y1a

Röder et al., 2020

Islet Amyloid Polypeptide (IAPP) C-term amidated

Synthetic

13-37

cryoEM

3.6

6zrf

Gallardo et al., 2020

Islet Amyloid Polypeptide (IAPP), amidated, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 1

13-37

cryoEM

3.8

7m61

Cao et al., 2021

Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant

Synthetic

15-37

cryoEM

3.9

6zrq

Gallardo et al., 2020

Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant

Synthetic

15-37

cryoEM

4.0

6zrr

Gallardo et al., 2020

Islet Amyloid Polypeptide (IAPP), amidated, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 4

6-37

cryoEM

4.1

7m65

Cao et al., 2021

Light Chain λ1, Antibody, human

Extracted from heart of a patient with cardiac AL amyloidosis

15-105

cryoEM

4.0

6ic3

Radamaker et al., 2019

Light Chain λ3, Antibody, human

Extracted from heart of a patient with cardiac AL amyloidosis, conformation A

9-49, 60-107

cryoEM

3.2

6z1o

Radamaker et al., 2021

Light Chain λ3, Antibody, human

Extracted from heart of a patient with cardiac AL amyloidosis, conformation B

9-49, 68-107

cryoEM

3.4

6z1i

Radamaker et al., 2021

Light Chain λ6, Antibody, human

Extracted from heart of a patient with amyloid cardiomyopathy

1-37, 66-105

cryoEM

3.3

6hud

Swuec et al., 2019

Nup98, human

Recombinant, polymorph 1

85-124

cryoEM

2.76

7q64

Ibáñez de Opakua et al., 2022

Nup98, human

Recombinant, polymorph 2

85-124

cryoEM

3.32

7q65

Ibáñez de Opakua et al., 2022

Nup98, human

Recombinant, polymorph 3

85-121

cryoEM

2.79

7q66

Ibáñez de Opakua et al., 2022

Nup98, human

Recombinant, polymorph 4

87-119

cryoEM

3.37

7q67

Ibáñez de Opakua et al., 2022

Orb2, Drosophila

Extracted from Drosophila brain

176-206

cryoEM

2.6

6vps

Hervás et al., 2020

Prion Protein, human

Recombinant

106-145

cryoEM

3.5

6uur

Glynn et al., 2020

Prion Protein, human, V129, F198S

Extracted from patient with Gerstmann-Sträussler-Scheinker disease, type I filament

80-141

cryoEM

3.29

7umq

Hallinan et al., 2022

Prion Protein, human, V129, F198S

Extracted from patient with Gerstmann-Sträussler-Scheinker disease, type IIb filament

80-141

cryoEM

3.13

7un5

Hallinan et al., 2022

Prion Protein, human

Recombinant

170-229

cryoEM

2.7

6lni

Wang et al., 2020

Prion Protein, human, E196K Inherited Mutation

Recombinant

175-217

cryoEM

3.07

7dwv

Wang et al., 2021

Prion Protein, mouse, PrP23-144

Recombinant, polymorph 1

108-141

cryoEM

3.92

8dja

Li et al., 2022

Prion Protein, human, Y145Stop mutation

Recombinant

108-141

cryoEM

2.86

7rl4

Li et al., 2022

Prion Protein, Syrian hamster

Recombinant, prepared in acidic solution

119-143

cryoEM

2.20

7yat

Chen et al., 2022

Prion Protein, Syrian hamster, infectious, 263K strain

Extracted from clinically ill hamster brain

95-227

cryoEM

3.14

7lna

Kraus et al., 2021

Prion Protein, mouse, anchorless, aRML prion strain, infectious

Extracted from brains of terminally ill mice

93-230

cryoEM

3.00

7td6

Hoyt et al., 2022

Prion Protein, mouse, anchorless, aRML prion strain, infectious

Extracted from brains of terminally ill mice

94-225

cryoEM

2.70

7qig

Manka et al., 2022

Prion Protein, mouse, a22L prion strain, infectious

Extracted from brains of terminally ill mice

94-226

cryoEM

3.20

8efu

Hoyt et al., 2022

RIPK1(496-583) + RIPK3(388-518), human

Recombinant

448-462, 532-549

ssNMR

N/A

5v7z

Mompeán et al., 2018

RIPK3(388-518) human

Recombinant

448-469

cryoEM

4.24

7da4

Wu et al., 2021

RIPK3(418-518) human

Recombinant

447-475

ssNMR

N/A

7dac

Wu et al., 2021

Serum Amyloid A, mouse

Extracted from spleen of a mouse with systemic AA amyloidosis, morphology I

1-69

cryoEM

3.0

6dso

Liberta et al., 2019

Serum Amyloid A, mouse

Recombinant, seeded by ex vivo fibrils from mouse liver, morphology I

1-69

cryoEM

2.69

7ovt

Heerde et al., 2022

Serum Amyloid A, mouse

Extracted from spleen of a mouse with systemic AA amyloidosis, morphology II

1-69

cryoEM

3.5

6zch

Bansal et al., 2021

Serum Amyloid A, mouse

Recombinant, unseeded, in vitro morphology i

1-37

cryoEM

2.73

6zcf

Bansal et al., 2021

Serum Amyloid A, mouse

Recombinant, unseeded, in vitro morphology ii

1-37

cryoEM

2.95

6zcg

Bansal et al., 2021

Serum Amyloid A, human

Extracted from kidney of a human with AA amyloidosis, glomerular variant

2-55

cryoEM

2.7

6mst

Liberta et al., 2019

Serum Amyloid A, human

Extracted from kidney of a human with AA amyloidosis, vascular variant

2-69

cryoEM

2.56

7zky

Banerjee et al., 2022

Serum Amyloid A, feline

Extracted from kidney of a domestic short hair cat with AA amyloidosis

19-94

cryoEM

3.30

7zh7

Schulte et al., 2022

SH3 Domain of PI3-kinase

Recombinant

1-77

cryoEM

3.4

6r4r

Röder et al., 2019

Superoxide Dismutase

Recombinant, full-length

3-55, 86-153

cryoEM

2.95

7vzf

Wang et al., 2022

Tau 3R+4R, Alzheimer's, Paired Helical Filament

Extracted from brain of a human with Alzheimer's Disease

306-378

cryoEM

3.4

5o3l

Fitzpatrick et al., 2017

Tau 3R+4R Paired Helical Filament

Extracted from Alzheimers Patient Brain and Stained with PET ligand APN1607

304-380

cryoEM

3.00

7nrv

Shi et al., 2021

Tau 3R+4R Paired Helical Filament

Extracted from Alzheimers Patient Brain and Soaked with EGCG for 0 hours

304-379

cryoEM

3.40

7upe

Seidler et al., 2022

Tau 3R+4R Paired Helical Filament

Extracted from Alzheimers Patient Brain and Soaked with EGCG for 1 hour

306-379

cryoEM

3.30

7upf

Seidler et al., 2022

Tau 3R+4R Paired Helical Filament

Extracted from Alzheimers Patient Brain and Soaked with EGCG for 3 hours

306-379

cryoEM

3.80

7upg

Seidler et al., 2022

Tau 3R+4R Paired Helical Filament

Extracted from PrP Cerebral Amyloid Angiopathy Patient Brain

306-378

cryoEM

3.00

7mkf

Hallinan et al., 2021

Tau 3R+4R Paired Helical Filament

Extracted from Gerstmann-Sträussler-Scheinker Patient Brain

305-379

cryoEM

3.30

7mkh

Hallinan et al., 2021

Tau 3R+4R Paired Helical Filament

Extracted from Primary Age-Related Tauopathy Patient Brain Case 3

304-380

cryoEM

2.76

7nrq

Shi et al., 2021

Tau (297-391)

Recombinant, PHF-like polymorph, 200 mM MgCl2, 200 rpm, filament type 4a

304-379

cryoEM

3.20

7ql4

Lövestam et al., 2022

Tau (266-391) and 3R/(297-391)

Recombinant, PHF-like polymorph

304-379

cryoEM

3.46

7ymn

Li et al., 2022

Tau (297-391)

Recombinant, AD-like fold, LiCl, filament type 2c

304-378

cryoEM

3.29

7qjv

Lövestam et al., 2022

Tau 3R+4R, Alzheimer's, Straight Filament

Extracted from brain of a human with Alzheimer's Disease

306-378

cryoEM

3.4

5o3t

Fitzpatrick et al., 2017

Tau 3R+4R Straight Filament

Extracted from Alzheimers Patient Brain and Stained with PET ligand APN1607

304-380

cryoEM

3.55

7nrx

Shi et al., 2021

Tau 3R+4R Straight Filament

Extracted from PrP Cerebral Amyloid Angiopathy Patient Brain

306-378

cryoEM

3.07

7mkg

Hallinan et al., 2021

Tau 3R+4R Straight Filament Conformation 1

Extracted from Primary Age-Related Tauopathy Patient Brain Case 3

304-380

cryoEM

2.68

7nrs

Shi et al., 2021

Tau 3R+4R Straight Filament Conformation 2

Extracted from Primary Age-Related Tauopathy Patient Brain Case 3

304-380

cryoEM

2.68

7nrt

Shi et al., 2021

Tau (297-408) S396D, S400D, T403D

Recombinant, filament type 42a

304-379

cryoEM

3.13

7qki

Lövestam et al., 2022

Tau (258-391)

Recombinant, phosphoglycerate, 700rpm, filament type 39a

304-379

cryoEM

2.80

7qkk

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, MgCl2 and NaCl, filament type 14a

304-379

cryoEM

2.57

7qku

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, KCl, filament type 10b

305-388

cryoEM

2.59

7r5h

Lövestam et al., 2022

Tau 4R, CTE Type I

Extracted from brain of a patient with Chronic Traumatic Encephalopathy

305-379

cryoEM

2.3

6nwp

Falcon et al., 2019

Tau 4R, CTE Type I

Extracted from brain of a patient with Chronic Traumatic Encephalopathy, complex with PET ligand flortaucipir

305-379

cryoEM

2.6

8byn

Shi et al., 2022

Tau 4R, CTE Type II

Extracted from brain of a patient with Chronic Traumatic Encephalopathy

305-379

cryoEM

3.4

6nwq

Falcon et al., 2019

Tau (297-391)

Recombinant, CTE type II-like polymorph, filament type 8a

305-379

cryoEM

2.81

7qjw

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, CTE-like fold, MgSO4, NaCl, filament type 15b

306-378

cryoEM

3.16

7qkx

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, CTE-like fold, MgSO4, NaCl, filament type 15c

306-377

cryoEM

3.13

7ql0

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, CTE-like fold, MgSO4, NaCl, filament type 15a

309-377

cryoEM

3.23

7qkv

Lövestam et al., 2022

Tau (266-391)

Recombinant, CTE-like fold, phosphate-buffered saline, filament type 23a

306-378

cryoEM

3.34

7ql1

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, LiCl, filament type 9b

305-378

cryoEM

3.40

7qjz

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, KCl, filament type 10a

306-379

cryoEM

1.92

7qk5

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, NaCl, filament type 8b

308-378

cryoEM

3.32

7ql3

Lövestam et al., 2022

Tau (297-394)

Recombinant, phosphate buffered saline, filament type 35d

305-379

cryoEM

3.03

7qk1

Lövestam et al., 2022

Tau (300-391)

Recombinant, phosphate buffered saline, filament type 36a

308-378

cryoEM

2.61

7qk2

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, MgCl2, NaCl, filament type 14b

305-379

cryoEM

3.26

7qkj

Lövestam et al., 2022

Tau (266-391)+(297-391)

Recombinant, NaHCO3, NaCl, filament type 16a

304-379

cryoEM

2.75

7r4t

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, LiCl, filament type 9a

305-379

cryoEM

3.14

7qjy

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, ZnCl2, filament type 11a

304-379

cryoEM

2.07

7qkl

Lövestam et al., 2022

Tau (297-391)

Recombinant, 700 rpm, filament type 34b

304-378

cryoEM

2.99

7qjx

Lövestam et al., 2022

Tau 3R

Extracted from brain of a human with Pick's Disease

254-274, 305-378

cryoEM

3.2

6gx5

Falcon et al., 2018

Tau (297-391)

Recombinant, spindle-like fold

304-362

cryoEM

2.54

7ypg

Li et al., 2022

Tau 4R

Extracted from brain of a human with Corticobasal Degeneration (CBD), Filament Type I

274-380

cryoEM

3.2

6tjo

Zhang et al., 2020

Tau 4R

Extracted from Argyrophilic Grain Disease (AGD) Patient Brain, Filament Type 1

273-387

cryoEM

3.30

7p6d

Shi et al., 2021

Tau 4R

Extracted from brain of a human with Corticobasal Degeneration (CBD), Filament Type II

274-380

cryoEM

3.0

6tjx

Zhang et al., 2020

Tau 4R

Extracted from Argyrophilic Grain Disease (AGD) Patient Brain, Filament Type 2

274-381

cryoEM

3.40

7p6e

Shi et al., 2021

Tau 4R

Extracted from Progressive Supranuclear Palsy (PSP) Patient Brain

272-381

cryoEM

2.70

7p65

Shi et al., 2021

Tau 4R

Extracted from Progressive Supranuclear Palsy (PSP) Patient Brain, Case 1

272-381

cryoEM

4.20

7u0z

Chang et al., 2022

Tau 4R

Extracted from Globular Glial Tauopathy (GGT) Patient Brain, Filament Type 1

272-379

cryoEM

3.00

7p66

Shi et al., 2021

Tau 4R

Extracted from Globular Glial Tauopathy (GGT) Patient Brain, filament type 2

272-379

cryoEM

3.10

7p67

Shi et al., 2021

Tau 4R

Extracted from Globular Glial Tauopathy (GGT) Patient Brain, Filament Type 3

272-379

cryoEM

2.90

7p68

Shi et al., 2021

Tau 4R

Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy (LNT) Patient Brain, Filament Type 1a

272-379

cryoEM

1.90

7p6a

Shi et al., 2021

Tau 4R

Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy (LNT) Patient Brain, Filament Type 1b

272-379

cryoEM

2.50

7p6b

Shi et al., 2021

Tau 4R

Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy (LNT) Patient Brain, Filament Type 2

272-379

cryoEM

2.20

7p6c

Shi et al., 2021

Tau40 and RNA

Recombinant and grown with RNA

391-426

cryoEM

3.40

7sp1

Abskharon et al., 2022

Tau 0N4R with phosphoserine

Recombinant, filament type 47a

376-441

cryoEM

1.86

7qky

Lövestam et al., 2022

Tau (266-391)(297-391)

Recombinant, CuCl2, filament type 12a

309-360, 305-335

cryoEM

2.83

7qkf

Lövestam et al., 2022

Tau 4R

Recombinant, Heparin Induced, Snake Polymorph

272-330

cryoEM

3.3

6qjh

Zhang et al., 2019

Tau 4R

Recombinant, Heparin Induced, Twister Polymorph

274-292, 304-321

cryoEM

3.3

6qjm

Zhang et al., 2019

Tau 4R

Recombinant, Heparin Induced, Jagged Polymorph

274-290, 304-321

cryoEM

3.5

6qjp

Zhang et al., 2019

Tau (258-391)

Recombinant, heparan sulfate, 700 rpm, filament type 40a

275-328

cryoEM

2.27

7qk6

Lövestam et al., 2022

Tau (258-391)

Recombinant, phosphoglycerate, 700 rpm, filament type 39a

275-328

cryoEM

3.36

7qkg

Lövestam et al., 2022

Tau (266-391) S356D

Recombinant, KCl, filament type 44a

275-328

cryoEM

2.32

7qkw

Lövestam et al., 2022

Tau (244-391)

Recombinant, Na4P2O7, filament type 20a

275-324

cryoEM

2.95

7ql2

Lövestam et al., 2022

Tau (258-391)

Recombinant, 700 rpm, filament type 38a

270-330

cryoEM

2.44

7qk3

Lövestam et al., 2022

Tau (266-391) S356D

Recombinant, NaCl, filament type 45a

274-328

cryoEM

2.66

7qkm

Lövestam et al., 2022

Tau 3R

Recombinant, Heparin Induced

272-274,306-330

cryoEM

3.5

6qjq

Zhang et al., 2019

Tau (258-391)

Recombinant, sodium azide, filament type 41a

277-317

cryoEM

3.17

7qkh

Lövestam et al., 2022

Tau (305-379)

Recombinant, filament type 27a

307-317

cryoEM

2.65

7qkz

Lövestam et al., 2022

TDP-43 (247-257)

synthetic

247-257

cryoEM

3.7

5w7v

Guenther et al., 2018

TDP-43 (311-360)

Recombinant

312-347

cryoEM

3.8

6n37

Cao et al., 2019

TDP-43 (311-360)

Recombinant

312-352

cryoEM

3.8

6n3b

Cao et al., 2019

TDP-43 (311-360)

Recombinant

311-360

cryoEM

3.3

6n3a

Cao et al., 2019

TDP-43 A315E (286-331)

Recombinant

288-319

cryoEM

3.3

6n3c

Cao et al., 2019

TDP-43 Low Complexity Domain (267-414)

Recombinant

276-414

cryoEM

3.2

7kwz

Li et al., 2021

TDP-43 ALS and FTLD Filament

Extracted from Patient with Amyotrophic Lateral Sclerosis and Fronto-temporal Lobar Degeneration

282-360

cryoEM

2.59

7py2

Arseni et al., 2021

TMEM106B Polymorph 1

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type C

120-254

cryoEM

2.90

7saq

Jiang et al., 2022

TMEM106B Fold I

Extracted from Patient with Alzheimer's Disease, case 1

120-254

cryoEM

2.64

7qvc

Schweighauser et al., 2022

TMEM106B Fold II-a

Extracted from Patient with Multiple System Atrophy, case 19

120-254

cryoEM

3.38

7qwg

Schweighauser et al., 2022

TMEM106B Fold II-b

Extracted from Patient with Multiple System Atrophy, case 19

120-254

cryoEM

3.47

7qwl

Schweighauser et al., 2022

TMEM106B Fold III

Extracted from Patient with Multiple System Atrophy, case 17

120-254

cryoEM

2.76

7qwm

Schweighauser et al., 2022

TMEM106B singlet filament

Extracted from Patient with Progressive Supranuclear Palsy, case 2

120-254

cryoEM

3.00

7u10

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type A, case 1

120-254

cryoEM

3.20

7u11

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type A, case 2

120-254

cryoEM

3.50

7u12

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type A, case 4

120-254

cryoEM

2.90

7u13

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type C, case 8

120-254

cryoEM

4.50

7u14

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type B, case 7

120-254

cryoEM

3.00

7u15

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type A, all cases combined

120-254

cryoEM

2.70

7u16

Chang et al., 2022

TMEM106B T185S singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type B, all cases combined

120-254

cryoEM

3.00

7u17

Chang et al., 2022

TMEM106B T185S singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type A, all cases combined

120-254

cryoEM

2.70

7u18

Chang et al., 2022

TMEM106B

Extracted from brain of 101 year old human with no diagnosed disease

120-254

cryoEM

3.40

7x83

Fan et al., 2022

TMEM106B

Extracted from brain of patient with Parkinsons Disease Dementia

120-254

cryoEM

3.00

7x84

Fan et al., 2022

TMEM106B Polymorph 2

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type C

120-254

cryoEM

3.20

7sar

Jiang et al., 2022

TMEM106B Fold I-d

Extracted from Patient with Multiple System Atrophy, case 18

120-254

cryoEM

3.64

7qvf

Schweighauser et al., 2022

TMEM106B Polymorph 3

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type C

120-254

cryoEM

3.70

7sas

Jiang et al., 2022

Transthyretin, V30M

Extracted from heart of a human with hereditary V30M ATTR Amyloidosis

11-35, 57-123

cryoEM

3.0

6sdz

Schmidt et al., 2019

Transthyretin, wildtype

Extracted from the heart a Senile Systemic Amyloidosis Patient

11-35, 57-123

cryoEM

2.78

8ade

Steinebrei et al., 2022

Transthyretin, V30M

Extracted from the Vitreous Body of the Eye of an Amyloid Transthyretin Amyloidosis (ATTR) Patient

11-35, 57-123

cryoEM

3.22

7ob4

Iakovleva et al., 2021