Amyloid Atlas 2022Amyloid Atlas 2022

Amyloid Fibril structures illustrated by Michael Sawaya. To see high resolution images of the amyloid fibril, click on thumbnail images, or download the complete atlas: colored by residue (pptx) or colored by energy (pptx). This page was last updated on January 24, 2022. 127 amyloid fibrils listed. See our accompanying review: The expanding amyloid family: Structure, stability, function, and pathogenesis, Cell, Vol 184, Issue 19, Sept. 16, 2021, pp. 4857-4873..

Protein
Source
Residues Ordered
Method
Resolution (Å)
Residue Map
Energy Map
PDB ID
Reference
Amyloid-β(1-42)

Recombinant

17-42

ssNMR

N/A

2beg

Lührs et al., 2005

Amyloid-β(1-40) Iowa Mutation D23N

Recombinant

15-40

ssNMR

N/A

2lnq

Qiang et al., 2012

Amyloid-β(1-40) (+)stagger

Recombinant

9-40

ssNMR

N/A

2lmn

Paravastu et al., 2008

Amyloid-β(1-40) (-)stagger

Recombinant

9-40

ssNMR

N/A

2lmo

Paravastu et al., 2008

Amyloid-β(1-40) (+)stagger

Recombinant

9-40

ssNMR

N/A

2lmp

Paravastu et al., 2008

Amyloid-β(1-40) (-)stagger

Recombinant

9-40

ssNMR

N/A

2lmq

Paravastu et al., 2008

Amyloid-β(1-40) Iowa Mutation D23N

Recombinant

15-40

ssNMR

N/A

2mpz

Sgourakis et al., 2015

Amyloid-β(1-40)

Recombinant, seeded from brain of a human with Alzheimers Disease

1-40

ssNMR

N/A

2m4j

Lu et al., 2013

Amyloid-β(1-42)

Recombinant

16-40

CryoEM

5.0

5aef

Schmidt et al., 2015

Amyloid-β(20-34)(L-isoAsp23)

Synthetic

20-34

MicroED

1.1

6nb9

Warmack et al., 2019

Amyloid-β(20-34)

Synthetic

20-34

MicroED

1.1

6oiz

Warmack et al., 2019

Amyloid-β(1-42)

Recombinant

11-42

ssNMR

N/A

2mxu

Xiao et al., 2015

Amyloid-β(1-42)

Recombinant

14-42

ssNMR

N/A

5kk3

Colvin et al., 2016

Amyloid-β(1-42)

Recombinant

14-42

ssNMR

N/A

2nao

Wälti et al., 2016

Amyloid-β(1-40) E22Δ Osaka mutation

Recombinant

1-40

ssNMR

N/A

2mvx

Schütz et al., 2015

Amyloid-β(1-42)

Recombinant

1-42

cryoEM

4.0

5oqv

Gremer et al., 2017

Amyloid-β

extracted from brain of a human with Alzheimers Disease (meningeal tissue)

1-40

cryoEM

4.4

6shs

Kollmer et al., 2019

Amyloid-β(1-40)

seeded with fibrils extracted from brain of a human with Alzheimers Disease (cortical tissue)

10-40

cryoEM

2.77

6w0o

Ghosh et al., 2021

Amyloid-β(1-40)

Recombinant

11-40

ssNMR

N/A

6ti5

Cerofolini et al., 2020

Amyloid-β(1-40 and 1-42 co-fibril)

Recombinant

11-40, 11-42

ssNMR

N/A

6ti6

Cerofolini et al., 2020

Amyloid-β(1-42)

Type 1 fibrils extracted from the brain of a patient with Alzheimers Disease

9-42

cryoEM

2.5

7q4b

Yang et al., 2021

Amyloid-β(1-42)

Type 2 fibrils extracted from the brain of a patient with Alzheimers Disease

12-42

cryoEM

2.8

7q4m

Yang et al., 2021

α-synuclein wt

Recombinant

43-97

ssNMR

N/A

2n0a

Tuttle et al., 2016

α-synuclein H50Q

Recombinant

36-99

cryoEM

3.3

6peo

Boyer et al., 2019

α-synuclein H50Q

Recombinant

36-99

cryoEM

3.6

6pes

Boyer et al., 2019

α-synuclein A53T

Recombinant

37-99

cryoEM

3.5

6lrq

Sun et al., 2020

α-synuclein MSA Case 2, Type II-2

extracted from brain of a human with Multiple Systems Atrophy (MSA)

14-99

cryoEM

3.1

6xyq

Schweighauser et al., 2020

α-synuclein MSA Case 2, Type II-1

extracted from brain of a human with Multiple Systems Atrophy (MSA)

14-99

cryoEM

3.3

6xyp

Schweighauser et al., 2020

α-synuclein MSA Case 1, Type I

extracted from brain of a human with Multiple Systems Atrophy (MSA)

14-99

cryoEM

2.6

6xyo

Schweighauser et al., 2020

α-synuclein N-acetylated, 1-103

Recombinant

37-96

cryoEM

3.4

6osm

Ni et al., 2019

α-synuclein rod polymorph

Recombinant

38-97

cryoEM

3.5

6cu7

Li et al., 2018

α-synuclein N-acetylated, 1-122

Recombinant

39-97

cryoEM

3.0

6osl

Ni et al., 2019

α-synuclein N-acetylated, 1-140

Recombinant

37-97

cryoEM

2.8

6osj

Ni et al., 2019

α-synuclein

Recombinant

37-99

cryoEM

3.1

6a6b

Li et al., 2018

α-synuclein (1-121)

Recombinant

38-95

cryoEM

3.4

6h6b

Guerrero-Ferreira et al., 2018

α-synuclein

Recombinant

43-83

cryoEM

3.6

6cu8

Li et al., 2018

α-synuclein polymorph 2b

Recombinant

9-24, 35-93

cryoEM

3.5

6rtb

Guerrero-Ferreira et al., 2019

α-synuclein polymorph 2b

Recombinant

14-25, 36-96

cryoEM

3.4

6sst

Guerrero-Ferreira et al., 2019

α-synuclein polymorph 2a

Recombinant

14-25, 36-95

cryoEM

3.1

6rt0

Guerrero-Ferreira et al., 2019

α-synuclein polymorph 2a

Recombinant

14-25, 36-96

cryoEM

3.0

6ssx

Guerrero-Ferreira et al., 2019

α-synuclein E46K

Recombinant

36-98

cryoEM

2.5

6ufr

Boyer et al., 2020

α-synuclein E46K

Recombinant

45-99

cryoEM

3.37

6l4s

Zhao et al., 2020a

α-synuclein phospho-Y39 twist-dimer

Semisynthetic

1-100

cryoEM

3.22

6l1t

Zhao et al., 2020b

α-synuclein phospho-Y39 twist-trimer

Semisynthetic

1-100

cryoEM

3.37

6l1u

Zhao et al., 2020b

α-synuclein wild type

Recombinant, seeded with E46K hereditary mutation

46-96

cryoEM

3.8

7c1d

Long et al., 2021

α-synuclein G51D hereditary mutation

Recombinant

50-98

cryoEM

3.02

7e0f

Sun et al., 2021

α-synuclein N-terminal Truncation 41-140

Recombinant

46-96

cryoEM

3.2

7lc9

McGlinchey et al., 2021

α-synuclein Type 1A Filaments

Recombinant, seeded from Multiple Systems Atrophy Case 2

37-97

cryoEM

3.47

7nca

Lovestam et al., 2021

α-synuclein Type 2A Filaments

Recombinant, seeded from Multiple Systems Atrophy Case 2

37-97

cryoEM

3.43

7ncg

Lovestam et al., 2021

α-synuclein Type 1B Filaments

Recombinant, seeded from Multiple Systems Atrophy Case 1

14-91

cryoEM

3.84

7nch

Lovestam et al., 2021

α-synuclein Type 2B Filaments

Recombinant, seeded from Multiple Systems Atrophy Case 1

14-91

cryoEM

3.55

7nci

Lovestam et al., 2021

α-synuclein Type 2AB Filaments

Recombinant, seeded from Multiple Systems Atrophy Case 1

14-91

cryoEM

4.23

7ncj

Lovestam et al., 2021

α-synuclein Type 3 Filaments

Recombinant, seeded from Multiple Systems Atrophy Case 5

36-99

cryoEM

3.18

7nck

Lovestam et al., 2021

β-2-microglobulin

Recombinant

22-85

cryoEM

3.9

6gk3

Iadanza et al., 2018

β-2-microglobulin

Recombinant

20-41

ssNMR

N/A

2e8d

Iwata et al., 2006

β-endorphin

Recombinant

1-31

ssNMR

N/A

6tub

Seuring et al., 2020

CA150 WW2 Domain

Recombinant

3-33

ssNMR

N/A

2nnt

Ferguson et al., 2006

FUS LC Domain

Recombinant

37-97

ssNMR

N/A

5w3n

Murray et al., 2017

FUS LC Domain

Recombinant

112-150

cryoEM

2.62

6xfm

Lee et al., 2021

FUS LC Domain

Recombinant

34-124

cryoEM

2.9

7vqq

Sun et al., 2021

Glucagon

Synthetic

1-29

ssNMR

N/A

6nzn

Gelenter et al., 2019

HET-s (218-289)

Recombinant

224-283

ssNMR

N/A

2rnm

Wasmer et al., 2008

hnRNPA1

Recombinant

251-295

cryoEM

2.8

7bx7

Sun et al., 2020

hnRNPA2

Recombinant

251-295

cryoEM

3.1

6wqk

Lu et al., 2020

Islet Amyloid Polypeptide (IAPP) SUMO-tagged

Recombinant

14-37

cryoEM

3.7

6vw2

Cao et al., 2020

Islet Amyloid Polypeptide (IAPP) C-term amidated

Synthetic

13-37

cryoEM

4.2

6y1a

Roeder et al., 2020

Islet Amyloid Polypeptide (IAPP) C-term amidated

Synthetic

13-37

cryoEM

3.6

6zrf

Gallardo et al., 2020

Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant

Synthetic

15-37

cryoEM

3.9

6zrq

Gallardo et al., 2020

Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant

Synthetic

15-37

cryoEM

4.0

6zrr

Gallardo et al., 2020

Islet Amyloid Polypeptide (IAPP), amidated, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 1

13-37

cryoEM

3.8

7m61

Cao et al., 2021

Islet Amyloid Polypeptide (IAPP), amidated, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 2

6-37

cryoEM

3.9

7m62

Cao et al., 2021

Islet Amyloid Polypeptide (IAPP), amidated, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 3

13-37

cryoEM

4.0

7m64

Cao et al., 2021

Islet Amyloid Polypeptide (IAPP), amidated, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 4

6-37

cryoEM

4.1

7m65

Cao et al., 2021

Light Chain λ1, Antibody

extracted from heart of a human with cardiac AL amyloidosis

15-105

cryoEM

4.0

6ic3

Radamaker et al., 2019

Light Chain λ3, Antibody, conformation A

extracted from heart of a human with cardiac AL amyloidosis

9-49, 60-107

cryoEM

3.2

6z1o

Radamaker et al., 2021

Light Chain λ3, Antibody, conformation B

extracted from heart of a human with cardiac AL amyloidosis

9-49, 68-107

cryoEM

3.4

6z1i

Radamaker et al., 2021

Light Chain λ6, Antibody

extracted from heart of a human with amyloid cardiomyopathy

1-37, 66-105

cryoEM

3.3

6hud

Swuec et al., 2019

Orb2

extracted from Drosophila brain

176-206

cryoEM

2.6

6vps

Hervás et al., 2020

Prion (hPrP)

Recombinant

106-145

cryoEM

3.5

6uur

Glynn et al., 2020

Prion (hPrP)

Recombinant

170-229

cryoEM

2.7

6lni

Wang et al., 2020

Prion (hPrP) E196K Inherited Mutation

Recombinant

175-217

cryoEM

3.07

7dwv

Wang et al., 2021

Prion Protein (PrP) Syrian hamster, infectious, 263K strain

Extracted from clinically ill hamster brain

95-227

cryoEM

3.14

7lna

Kraus et al., 2021

RIPK1+RIPK3

Recombinant

448-462, 532-549

ssNMR

N/A

5v7z

Mompeán et al., 2018

RIPK3 human

Recombinant

448-469

cryoEM

4.24

7da4

Wu et al., 2021

RIPK3 human

Recombinant

447-475

ssNMR

N/A

7dac

Wu et al., 2021

Serum Amyloid A, mouse, morphology I

extracted from spleen of a mouse with systemic AA amyloidosis

1-69

cryoEM

3.0

6dso

Liberta et al., 2019

Serum Amyloid A, mouse, morphology II

extracted from spleen of a mouse with systemic AA amyloidosis

1-69

cryoEM

3.5

6zch

Bansal et al., 2021

Serum Amyloid A, mouse, morphology i

Recombinant

1-37

cryoEM

2.73

6zcf

Bansal et al., 2021

Serum Amyloid A, mouse, morphology ii

Recombinant

1-37

cryoEM

2.95

6zcg

Bansal et al., 2021

Serum Amyloid A, human

extracted from kidney of a human with AA amyloidosis

2-55

cryoEM

2.7

6mst

Liberta et al., 2019

SH3 Domain of PI3-kinase

Recombinant

1-77

cryoEM

3.4

6r4r

Röder et al., 2019

Tau 3R+4R, Alzheimer's, Paired Helical Filament

extracted from brain of a human with Alzheimer's Disease

306-378

cryoEM

3.4

5o3l

Fitzpatrick et al., 2017

Tau 3R+4R Paired Helical Filament

Extracted from Alzheimers Patient Brain and Stained with PET ligand APN1607

304-330

cryoEM

3.00

7nrv

Shi et al., 2021

Tau 3R+4R Paired Helical Filament

Extracted from PrP Cerebral Amyloid Angiopathy Patient Brain

306-378

cryoEM

3.00

7mkf

Hallinan et al., 2021

Tau 3R+4R Paired Helical Filament

Extracted from Gerstmann-Sträussler-Scheinker Patient Brain

305-379

cryoEM

3.30

7mkh

Hallinan et al., 2021

Tau 3R+4R Paired Helical Filament

Extracted from Primary Age-Related Tauopathy Patient Brain Case 3

304-380

cryoEM

2.76

7nrq

Shi et al., 2021

Tau 3R+4R, Alzheimer's, Straight Filament

extracted from brain of a human with Alzheimer's Disease

306-378

cryoEM

3.4

5o3t

Fitzpatrick et al., 2017

Tau 3R+4R Straight Filament

Extracted from Alzheimers Patient Brain and Stained with PET ligand APN1607

304-380

cryoEM

3.55

7nrx

Shi et al., 2021

Tau 3R+4R Straight Filament

Extracted from PrP Cerebral Amyloid Angiopathy Patient Brain

306-378

cryoEM

3.07

7mkg

Hallinan et al., 2021

Tau 3R+4R Straight Filament Conformation 1

Extracted from Primary Age-Related Tauopathy Patient Brain Case 3

304-380

cryoEM

2.68

7nrs

Shi et al., 2021

Tau 3R+4R Straight Filament Conformation 2

Extracted from Primary Age-Related Tauopathy Patient Brain Case 3

304-380

cryoEM

2.68

7nrt

Shi et al., 2021

Tau 3R, Pick's

extracted from brain of a human with Pick's Disease

254-378 Δ275-305

cryoEM

3.2

6gx5

Falcon et al., 2018

Tau 4R, CTE Type 1

extracted from brain of a human with Chronic Traumatic Encephalopathy

305-379

cryoEM

2.3

6nwp

Falcon et al., 2019

Tau 4R, CTE Type 2

extracted from brain of a human with Chronic Traumatic Encephalopathy

305-379

cryoEM

3.4

6nwq

Falcon et al., 2019

Tau 4R, CBD Type 1

extracted from brain of a human with Corticobasal Degeneration

274-380

cryoEM

3.2

6tjo

Zhang et al., 2020

Tau 4R, CBD Type 2

extracted from brain of a human with Corticobasal Degeneration

274-380

cryoEM

3.0

6tjx

Zhang et al., 2020

Tau 4R AGD Filament Type 1

Extracted from Argyrophilic Grain Disease Patient Brain

273-387

cryoEM

3.30

7p6d

Shi et al., 2021

Tau 4R AGD Filament Type 2

Extracted from Argyrophilic Grain Disease Patient Brain

274-381

cryoEM

3.40

7p6e

Shi et al., 2021

Tau 4R PSP Filament

Extracted from Progressive Supranuclear Palsy Patient Brain

272-381

cryoEM

2.70

7p65

Shi et al., 2021

Tau 4R Filament GGT Type 1

Extracted from Globular Glial Tauopathy Patient Brain

272-379

cryoEM

3.00

7p66

Shi et al., 2021

Tau 4R Filament GGT Type 2

Extracted from Globular Glial Tauopathy Patient Brain

272-379

cryoEM

3.10

7p67

Shi et al., 2021

Tau 4R Filament GGT Type 3

Extracted from Globular Glial Tauopathy Patient Brain

272-379

cryoEM

2.90

7p68

Shi et al., 2021

Tau 4R Filament LNT Type 1a

Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy Patient Brain

272-379

cryoEM

1.90

7p6a

Shi et al., 2021

Tau 4R Filament LNT Type 1b

Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy Patient Brain

272-379

cryoEM

2.50

7p6b

Shi et al., 2021

Tau 4R Filament LNT Type 2

Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy Patient Brain

272-379

cryoEM

2.20

7p6c

Shi et al., 2021

Tau 4R, Snake Polymorph, Heparin Induced

Recombinant

272-330

cryoEM

3.3

6qjh

Zhang et al., 2019

Tau 4R, Twister Polymorph, Heparin Induced

Recombinant

274-292, 304-321

cryoEM

3.3

6qjm

Zhang et al., 2019

Tau 4R, Jagged Polymorph, Heparin Induced

Recombinant

274-290, 304-321

cryoEM

3.5

6qjp

Zhang et al., 2019

Tau 3R, Heparin Induced

Recombinant

272-330 Δ275-305

cryoEM

3.5

6qjq

Zhang et al., 2019

TDP-43 (247-257)

synthetic

247-257

cryoEM

3.7

5w7v

Guenther et al., 2018

TDP-43 (311-360)

Recombinant

312-347

cryoEM

3.8

6n37

Cao et al., 2019

TDP-43 (311-360)

Recombinant

312-352

cryoEM

3.8

6n3b

Cao et al., 2019

TDP-43 (311-360)

Recombinant

311-360

cryoEM

3.3

6n3a

Cao et al., 2019

TDP-43 A315E (286-331)

Recombinant

288-319

cryoEM

3.3

6n3c

Cao et al., 2019

TDP-43 Low Complexity Domain (267-414)

Recombinant

276-414

cryoEM

3.2

7kwz

Li et al., 2021

TDP-43 ALS and FTLD Filament

Extracted from Patient with Amyotrophic Lateral Sclerosis and Fronto-temporal Lobar Degeneration

282-360

cryoEM

2.59

7py2

Arseni et al., 2021

Transthyretin V30M

extracted from heart of a human with hereditary V30M ATTR Amyloidosis

11-35, 57-123

cryoEM

3.0

6sdz

Schmidt et al., 2019

Transthyretin Filament from ATTR, Eye

Extracted from the Vitreous Body of the Eye of an Amyloid Transthyretin Amyloidosis Patient

11-35, 57-123

cryoEM

3.22

7ob4

Iakovleva et al., 2021