Amyloid Atlas 2024Amyloid Atlas 2024

Amyloid Fibril structures illustrated by Michael Sawaya. Supported by National Institute on Aging. To see high resolution images of the amyloid fibril, click on thumbnail images. 379 amyloid fibril entries are listed. This page was last updated on April 24, 2024. See our accompanying review: The expanding amyloid family: Structure, stability, function, and pathogenesis, Cell, Vol 184, Issue 19, Sept. 16, 2021, pp. 4857-4873. Make your own amyloid illustrations automatically with Amyloid Illustrator.

Protein
Fibril Origins
Residues Ordered
Method
Resol- ution (Å)
Polarity Map
Energy Map
PDB ID
Reference
α-synuclein

Human, recombinant

43-83

cryoEM

3.6

6cu8

Li et al., 2018

α-synuclein

Human, recombinant

43-97

ssNMR

N/A

2n0a

Tuttle et al., 2016

α-synuclein

Human, recombinant, seeded from Multiple System Atrophy Case 5, filament type 3

36-99

cryoEM

3.18

7nck

Lövestam et al., 2021

α-synuclein H50Q mutant

Human, recombinant

36-99

cryoEM

3.3

6peo

Boyer et al., 2019

α-synuclein mixture of wild type and MAAAEKT insertion mutation after residue 22

human, extracted from patient with Juvenile-Onset Synucleinopathy, singlet filament

14-25,36-100

cryoEM

2.00

8bqv

Yang et al., 2023

α-synuclein mixture of wild type and MAAAEKT insertion mutation after residue 22

human, extracted from patient with Juvenile-Onset Synucleinopathy, doublet filament

14-25,36-100

cryoEM

2.30

8bqw

Yang et al., 2023

α-synuclein H50Q mutant

recombinant

36-99

cryoEM

3.6

6pes

Boyer et al., 2019

α-synuclein A53E mutant

human, recombinant

38-99

cryoEM

3.38

7uak

Sun et al., 2023

α-synuclein A53T mutant

recombinant

37-99

cryoEM

3.5

6lrq

Sun et al., 2020

α-synuclein N-acetylated, 1-103

recombinant

37-96

cryoEM

3.4

6osm

Ni et al., 2019

α-synuclein mixture of wild type and MAAAEKT insertion mutation after residue 22

human, recombinant, type 1 filaments

37-99

cryoEM

2.70

8ce7

Yang et al., 2023

α-synuclein mixture of wild type and MAAAEKT insertion mutation after residue 22

human, recombinant, type 2 filaments

40-97

cryoEM

2.70

8ceb

Yang et al., 2023

α-synuclein

recombinant, human, complex with ligand F0502B

37-97

cryoEM

2.6

7wmm

Tao et al., 2023 unpublished

α-synuclein

Human, recombinant, Thioflavin T ligand, conformation 1

37-97

cryoEM

2.9

7ynm

Tao et al., 2023 unpublished

α-synuclein

Human, recombinant, Thioflavin T ligand, conformation 2

37-97

cryoEM

2.9

7ynn

Tao et al., 2023 unpublished

α-synuclein

Human, recombinant, Pitssburgh compound B ligand, conformation 1

37-97

cryoEM

2.8

7yno

Tao et al., 2023 unpublished

α-synuclein

Human, recombinant, Pittsburgh compound B ligand, conformation 2

37-97

cryoEM

2.8

7ynq

Tao et al., 2023 unpublished

α-synuclein

Human, recombinant, BF227 ligand

37-97

cryoEM

2.8

7ynp

Tao et al., 2023 unpublished

α-synuclein

Human, recombinant, EB ligand

40-97

cryoEM

2.6

7ynl

Tao et al., 2023 unpublished

α-synuclein

Human, recombinant, Congo Red ligand (disordered)

37-99

cryoEM

3.1

7yng

Tao et al., 2023 unpublished

α-synuclein

Human, recombinant, C05-03 ligand (disordered)

37-97

cryoEM

2.9

7ynr

Tao et al., 2023 unpublished

α-synuclein

Human, recombinant, SIL5 ligand (disordered)

37-97

cryoEM

3.0

7yns

Tao et al., 2023 unpublished

α-synuclein

Human, recombinant, pFTAA ligand (disordered)

40-97

cryoEM

3.1

7ynt

Tao et al., 2023 unpublished

α-synuclein rod polymorph

recombinant, human

38-97

cryoEM

3.5

6cu7

Li et al., 2018

α-synuclein N-acetylated, 1-122

recombinant, human

39-97

cryoEM

3.0

6osl

Ni et al., 2019

α-synuclein N-acetylated, 1-140

recombinant, human

37-97

cryoEM

2.8

6osj

Ni et al., 2019

α-synuclein N-acetylated, 1-140,

recombinant, human

37-99

cryoEM

3.07

6a6b

Li et al., 2018

α-synuclein (1-121)

recombinant

38-95

cryoEM

3.4

6h6b

Guerrero-Ferreira et al., 2018

α-synuclein (1-140)

recombinant, human, induced by ferric iron

37-99

cryoEM

2.7

7xjx

Zhao et al., 2023

α-synuclein (1-140)

recombinant, human, non-acetylated, apo

37-99

cryoEM

2.8

7yk2

Zhang et al., 2023

α-synuclein (1-140)

recombinant, human, non-acetylated, with dLAG3 receptor

14-25,37-99

cryoEM

2.8

7yk8

Zhang et al., 2023

α-synuclein

recombinant, human, heparin-remodeled

37-94

cryoEM

3.50

7v4d

Tao et al., 2022 unpublished

α-synuclein A53T mutant

recombinant, human

37-100

cryoEM

3.40

7wnz

Huang et al., unpublished

α-synuclein

recombinant, human, seeded from a Parkinson's Disease patient, postmortem, filament type 4

36-95

cryoEM

3.40

7v49

Fan et al., 2023

α-synuclein

recombinant, human, seeded from a Parkinson's Disease patient, postmortem, minor polymorph

36-95

cryoEM

3.40

8h05

Fan et al., 2023

α-synuclein

human, extracted from Multiple System Atrophy Case 2, Type II-2 fibril

14-99

cryoEM

3.1

6xyq

Schweighauser et al., 2020

α-synuclein

human, extracted from Multiple System Atrophy brain, Case 2, Type II-1 fibril

14-99

cryoEM

3.3

6xyp

Schweighauser et al., 2020

α-synuclein

human, extracted from Multiple System Atrophy brain, Case 1, Type I fibril

14-99

cryoEM

2.6

6xyo

Schweighauser et al., 2020

α-synuclein E46K mutant

recombinant

45-99

cryoEM

3.37

6l4s

Zhao et al., 2020a

α-synuclein wild type

recombinant, seeded with E46K mutant

46-96

cryoEM

3.8

7c1d

Long et al., 2021

α-synuclein G51D hereditary mutation

recombinant

50-98

cryoEM

3.02

7e0f

Sun et al., 2021

α-synuclein

recombinant, human, recombinant, heparin-induced, polymorph 4

37-98

cryoEM

3.30

7v4c

Tao et al., 2022 unpublished

α-synuclein

recombinant, human, recombinant, heparin-induced, polymorph 1

14-25, 32-99

cryoEM

3.20

7v4a

Tao et al., 2022 unpublished

α-synuclein

Human, recombinant, polymorph 2b

14-25, 36-96

cryoEM

3.4

6sst

Guerrero-Ferreira et al., 2019

α-synuclein

Human, recombinant, polymorph 2b

9-24, 35-93

cryoEM

3.5

6rtb

Guerrero-Ferreira et al., 2019

α-synuclein

Human, recombinant, seeded from Multiple System Atrophy Case 2, fold A, doublet type 2

37-97

cryoEM

3.43

7ncg

Lövestam et al., 2021

α-synuclein

Human, recombinant, seeded from Multiple System Atrophy Case 1, fold B, doublet type 2

14-25, 36-91

cryoEM

3.55

7nci

Lövestam et al., 2021

α-synuclein

Human, recombinant, seeded from Multiple System Atrophy Case 1, folds A and B, doublet type 2

37-97

cryoEM

4.23

7ncj

Lövestam et al., 2021

α-synuclein

recombinant, seeded from Multiple System Atrophy

36-93

cryoEM

3.02

7ozh

Frieg et al., 2022

α-synuclein

recombinant, human, seeded from a Parkinson's Disease patient, mid-to-late stage 1, major polymorph

36-97

cryoEM

3.00

7xo1

Fan et al., 2023

α-synuclein

recombinant, human, seeded from a Parkinson's Disease patient, mid-to-late stage 4, filament type 1C

36-98

cryoEM

2.60

7xo3

Fan et al., 2023

α-synuclein

recombinant, human, seeded from a Parkinson's Disease patient, preclinical, filament type 1A

36-96

cryoEM

2.80

7v47

Fan et al., 2023

α-synuclein

recombinant, human, seeded from Parkinson's Disease patient, preclinical, major polymorph

36-96

cryoEM

2.80

8h03

Fan et al., 2023

α-synuclein

recombinant, human, seeded from a Parkinson's Disease patient, postmortem, filament type 1D

36-98

cryoEM

3.00

7v48

Fan et al., 2023

α-synuclein

recombinant, human, seeded from a Parkinson's Disease patient postmortem, major polymorph

36-98

cryoEM

3.00

8h04

Fan et al., 2023

α-synuclein

Human, recombinant, seeded from Dementia with Lewy Bodies Case 3, Fibril Class 2b, compact pore, type 1 warp

14-25,36-96

cryoEM

3.10

8cyw

Sokratian et al., 2023 BioRxiv

α-synuclein

Human, recombinant, spontaneous control

15-24,36-97

cryoEM

4.20

8cyr

Sokratian et al., 2023 BioRxiv

α-synuclein

Human, recombinant, seeded from Dementia with Lewy Bodies Case 1, Fibril Class 2b, extended pore, type 2 warp

15-24,36-97

cryoEM

3.10

8cys

Sokratian et al., 2023 BioRxiv

α-synuclein

Human, recombinant, seeded from Dementia with Lewy Bodies Case 2, Fibril Class 2b, extended pore, type 1 & 2 warp

15-24,36-97

cryoEM

3.50

8cyv

Sokratian et al., 2023 BioRxiv

α-synuclein

Human, recombinant, seeded from Dementia with Lewy Bodies Case 5, Fibril Class 2b, extended pore, type 1 & 2 warps

15-24,36-97

cryoEM

3.10

8cyy

Sokratian et al., 2023 BioRxiv

α-synuclein

Human, recombinant, seeded from Dementia with Lewy Bodies Case 7, Fibril Class 2b, extended pore, type 1 warp

15-24,36-97

cryoEM

2.90

8cz0

Sokratian et al., 2023 BioRxiv

α-synuclein

Human, recombinant, seeded from Dementia with Lewy Bodies Case 7, Fibril Class 2b, extended pore, type 2 warp

15-24,36-97

cryoEM

3.00

8cz1

Sokratian et al., 2023 BioRxiv

α-synuclein

Human, recombinant, seeded from Dementia with Lewy Bodies Case 10, Fibril Class 2b, extended pore, type 1 warp

15-24,36-97

cryoEM

3.20

8cz3

Sokratian et al., 2023 BioRxiv

α-synuclein

recombinant, human, recombinant, heparin-induced, polymorph 3

14-25, 32-99

cryoEM

3.10

7v4b

Tao et al., 2022 unpublished

α-synuclein A53T mutant

recombinant, human

35-99

cryoEM

2.70

7wo0

Huang et al., unpublished

α-synuclein

Human, recombinant, polymorph 2a

14-25, 36-95

cryoEM

3.1

6rt0

Guerrero-Ferreira et al., 2019

α-synuclein

Human, recombinant, polymorph 2a

14-25, 36-96

cryoEM

3.0

6ssx

Guerrero-Ferreira et al., 2019

α-synuclein E46K mutant

recombinant

36-98

cryoEM

2.5

6ufr

Boyer et al., 2020

α-synuclein

Human, recombinant, seeded from Multiple System Atrophy Case 2, fold A, doublet type 1

37-97

cryoEM

3.47

7nca

Lövestam et al., 2021

α-synuclein

recombinant, human, seeded from a Parkinson's Disease patient, mid-to-late stage 1, minor polymorph

36-97

cryoEM

3.00

7xo0

Fan et al., 2023

α-synuclein

recombinant, human, seeded from a Parkinson's Disease patient, mid-to-late stage 4, minor polymorph

36-97

cryoEM

3.00

7xo2

Fan et al., 2023

α-synuclein

recombinant, seeded from Multiple System Atrophy Case 1, fold B, doublet type 1

14-25, 36-91

cryoEM

3.84

7nch

Lövestam et al., 2021

α-synuclein

recombinant, seeded from brain of Parkinson's Disease Patient

14-25,36-96

cryoEM

3.30

7ozg

Frieg et al., 2022

α-synuclein

Human, recombinant, seeded from Dementia with Lewy Bodies Case 3, Fibril Class 2a, compact pore, type 1 warp

14-25,36-96

cryoEM

3.00

8cyx

Sokratian et al., 2023 BioRxiv

α-synuclein

Human, recombinant, seeded from Dementia with Lewy Bodies Case 1, Fibril Class 2a, extended pore, type 1 warp

15-24,36-97

cryoEM

3.00

8cyt

Sokratian et al., 2023 BioRxiv

α-synuclein

Human, recombinant, seeded from Dementia with Lewy Bodies Case 7, Fibril Class 2a, extended pore, type 1 warp

15-24,36-97

cryoEM

3.00

8cz2

Sokratian et al., 2023 BioRxiv

α-synuclein

Human, recombinant, seeded from Dementia with Lewy Bodies Case 10, Fibril Class 2a, extended pore, type 1 warp

15-24,36-97

cryoEM

3.20

8cz6

Sokratian et al., 2023 BioRxiv

α-synuclein, human

recombinant, Lipidic, Polymorph L2B

14-24,33-96

cryoEM

3.05

8ads

Frieg et al., 2022b

α-synuclein, human

recombinant, Lipidic, Polymorph L3A

14-19,33-97

cryoEM

2.76

8aex

Frieg et al., 2022b

α-synuclein, human

recombinant, Lipidic, Polymorph L1A

1-99

cryoEM

3.24

8adu

Frieg et al., 2022b

α-synuclein, human

recombinant, Lipidic, Polymorph L1B

1-99

cryoEM

2.98

8adv

Frieg et al., 2022b

α-synuclein, human

recombinant, Lipidic, Polymorph L1C

1-99

cryoEM

2.95

8adw

Frieg et al., 2022b

α-synuclein

human, recombinant, heparin-remodeled, lipidic polymorph L2A

14-24, 33-96

cryoEM

3.22

8a4l

Frieg et al., 2022

α-synuclein

human, extracted from Parkinson's Disease Dementia patient brain; identical fold as Parkinson's Disease and Dementia with Lewy bodies

14-22, 31-100

cryoEM

2.16

8a9l

Yang et al., 2022

α-synuclein

human, recombinant, seeded with fibrils from a patient with Dementia with Lewy bodies

30-103

ssNMR

N/A

8fpt

Dhavale et al., 2023

α-synuclein phospho-Y39 twist-dimer

Semisynthetic

1-100

cryoEM

3.22

6l1t

Zhao et al., 2020b

α-synuclein phospho-Y39 twist-trimer

Semisynthetic

1-100

cryoEM

3.37

6l1u

Zhao et al., 2020b

α-synuclein N-terminal Truncation 41-140

recombinant

46-96

cryoEM

3.2

7lc9

McGlinchey et al., 2021

α-synuclein Filaments

recombinant, formed in the presence of Tau

37-79

cryoEM

4.00

7l7h

Hojjatian et al., 2021

Amyloid-β(1-42)

recombinant

17-42

ssNMR

N/A

2beg

Lührs et al., 2005

Amyloid-β(1-40) Iowa Mutation D23N

recombinant

15-40

ssNMR

N/A

2lnq

Qiang et al., 2012

Amyloid-β(1-40) (+)stagger

recombinant

9-40

ssNMR

N/A

2lmn

Paravastu et al., 2008

Amyloid-β(1-40) (-)stagger

recombinant

9-40

ssNMR

N/A

2lmo

Paravastu et al., 2008

Amyloid-β(1-40)

recombinant

11-40

ssNMR

N/A

6ti5

Cerofolini et al., 2020

Amyloid-β(1-40 and 1-42 co-fibril)

human, recombinant

11-40, 11-42

ssNMR

N/A

6ti6

Cerofolini et al., 2020

Amyloid-β(1-40) (+)stagger

recombinant

9-40

ssNMR

N/A

2lmp

Paravastu et al., 2008

Amyloid-β(1-40) (-)stagger

recombinant

9-40

ssNMR

N/A

2lmq

Paravastu et al., 2008

Amyloid-β(1-40) Iowa Mutation D23N

recombinant

15-40

ssNMR

N/A

2mpz

Sgourakis et al., 2015

Amyloid-β(1-40)

recombinant, seeded from brain of a human with Alzheimers Disease

1-40

ssNMR

N/A

2m4j

Lu et al., 2013

Amyloid-β(1-42)

recombinant

16-40

CryoEM

5.0

5aef

Schmidt et al., 2015

Amyloid-β(1-42)

recombinant, seeded from the brain of a human with Alzheimers Disease, type B fibril

1-42

CryoEM

2.76

8eze

Lee et al., 2023

Amyloid-β(1-40)

Seeded with fibrils extracted from brain of a human with Alzheimers Disease (cortical tissue)

10-40

cryoEM

2.77

6w0o

Ghosh et al., 2021

Amyloid-β

recombinant, unseeded, morphology i

13-40

cryoEM

2.59

8ot1

Pfeiffer et al., 2023

Amyloid-β

recombinant, unseeded, morphology ii

13-40

cryoEM

2.73

8ot3

Pfeiffer et al., 2023

Amyloid-β

Extracted from brain of a human with Alzheimers Disease (meningeal tissue)

1-40

cryoEM

4.4

6shs

Kollmer et al., 2019

Amyloid-β

recombinant, seeded with meningeal tissue of Alzheimer's patients, morphology I

1-37

cryoEM

2.59

8ot4

Pfeiffer et al., 2023

Amyloid-β(20-34)

Synthetic

20-34

MicroED

1.1

6oiz

Warmack et al., 2019

Amyloid-β(20-34)(L-isoAsp23)

Synthetic

20-34

MicroED

1.1

6nb9

Warmack et al., 2019

Amyloid-β(1-42) E22G

Human, extracted from AppNL-G-F familial AD mouse model brain

1-38

CryoEM

3.0

8bfa

Leistner et al., 2023

Amyloid-β(1-42) E22G

Human, extracted from AppNL-G-F familial AD mouse model brain, and stained with methoxy-X04

1-38

CryoEM

3.2

8bfb

Leistner et al., 2023

Amyloid-β(1-42)

recombinant, seeded from the brain of a human with Alzheimers Disease, type A fibril

12-42

CryoEM

2.83

8ezd

Lee et al., 2023

Amyloid-β(1-42)

recombinant

11-42

ssNMR

N/A

2mxu

Xiao et al., 2015

Amyloid-β(1-42)

recombinant

14-42

ssNMR

N/A

5kk3

Colvin et al., 2016

Amyloid-β(1-42)

recombinant

14-42

ssNMR

N/A

2nao

Wälti et al., 2016

Amyloid-β(1-42), human

Extracted from the brain of a patient with Alzheimers Disease, type I filaments

9-42

cryoEM

2.5

7q4b

Yang et al., 2022

Amyloid-β(1-42), human

Aqueous extracts from the brain of a patient with Alzheimers Disease, type I filaments

9-42

cryoEM

2.9

8azs

Stern et al., 2023

Amyloid-β(1-42), human

Extracted from the brain of a patient with Alzheimers Disease, type II filaments

12-42

cryoEM

2.8

7q4m

Yang et al., 2022

Amyloid-β(1-42), human

Aqueous extracts from the brain of a patient with Alzheimers Disease, type II filaments

12-42

cryoEM

3.7

8azt

Stern et al., 2023

Amyloid-β(1-42) E22G arctic mutation, human

Extracted from the brain of a patient with Alzheimers Disease

12-42

cryoEM

2.8

8bfz

Yang et al., 2023

Amyloid-β(1-40) E22G arctic mutation, human

Extracted from the brain of a patient with Alzheimers Disease

11-40

cryoEM

1.99

8bg0

Yang et al., 2023

Amyloid-β(1-40) E22G arctic mutation, human protein in mouse model

Extracted from the brain of a mouse with Alzheimers Disease

1-37

cryoEM

3.50

8bg9

Yang et al., 2023

Amyloid-β(1-42)

Synthetic, glycosylated at Tyr10

6-42

cryoEM

3.10

7f29

Liu et al., 2021

Amyloid-β(1-40) E22Δ Osaka mutation

recombinant

1-40

ssNMR

N/A

2mvx

Schütz et al., 2015

Amyloid-β(1-42)

recombinant

1-42

cryoEM

4.0

5oqv

Gremer et al., 2017

Antimicrobial peptide uperin 3.5

Synthetic, Mjobergs toadlet

1-17

cryoEM

3.0

7qv5

Bücker et al., 2022

Antimicrobial peptide aurein 3.3

Synthetic, blue-thighed tree frog

1-17

cryoEM

3.5

7qv6

Bücker et al., 2022

β-2-microglobulin

recombinant

22-85

cryoEM

3.9

6gk3

Iadanza et al., 2018

β-2-microglobulin

recombinant, fibril form 4PF

21-84

cryoEM

2.8

8a7q

Wilkinson et al., 2023

β-2-microglobulin D76N mutation

recombinant, fibril form 2PFa

6-90

cryoEM

3.0

8a7t

Wilkinson et al., 2023

β-2-microglobulin ΔN6 mutation

recombinant, fibril form 2PFa

6-93

cryoEM

3.0

8a7o

Wilkinson et al., 2023

β-2-microglobulin ΔN6 mutation

recombinant, fibril form 2PFb

6-92

cryoEM

3.4

8a7p

Wilkinson et al., 2023

β-2-microglobulin

recombinant

20-41

ssNMR

N/A

2e8d

Iwata et al., 2006

β-endorphin

recombinant

1-31

ssNMR

N/A

6tub

Seuring et al., 2020

CA150 WW2 Domain

recombinant

3-33

ssNMR

N/A

2nnt

Ferguson et al., 2006

De novo, Pyrene IDP

Synthetic, intrinsically disordered short peptide forms fibrils, pH 2.0

1-6

cryoEM

3.10

7uuq

Guo et al., 2023

De novo, Pyrene IDP

Synthetic, intrinsically disordered short peptide forms fibrils, pH 4.0, 2mM Ca2+

1-6

cryoEM

3.00

8gi5

Guo et al., 2023

De novo, Nitrobenzoxadiazole-ffsy D-peptide

Synthetic, class 2 fibril, induces cells to form spheroids

1-5

cryoEM

3.20

8dst

Guo et al., 2023

De novo, Nitrobenzoxadiazole-ffsy D-peptide

Synthetic, class 1 fibril, induces cells to form spheroids

1-5

cryoEM

3.10

7t6e

Guo et al., 2023

De novo, Biphenyl-4-peptidyl-ffsy D-peptide

Synthetic, induces cells to form spheroids

1-5

cryoEM

2.60

8fof

Guo et al., 2023

De novo, catalytic Amyloid Fibril, Ac-LHLHLRL-NH2, p-nitrophenyl hydrolase

Synthetic

1-7

cryoEM

3.80

8b3a

Heerde et al., 2023

De novo, Virus Enhancing Amyloid Fibril, PNF-18, CKFKFQF

Synthetic

1-7

cryoEM

2.86

8okr

Heerde et al., 2023

De novo, Enzyme-cleaved Amyloid Peptide (EAP2), abeta-2, GPLGMLGGVVIA, polymorph 1

Synthetic

1-12

cryoEM

2.35

8gz8

Wang et al., 2023

De novo, Enzyme-cleaved Amyloid Peptide (EAP2), abeta-2, GPLGMLGGVVIA, polymorph 2

Synthetic

1-12

cryoEM

2.62

8gz9

Wang et al., 2023

FUS LC Domain

recombinant

37-97

ssNMR

N/A

5w3n

Murray et al., 2017

FUS LC Domain

recombinant

112-150

cryoEM

2.62

6xfm

Lee et al., 2021

FUS LC Domain

recombinant

34-124

cryoEM

2.9

7vqq

Sun et al., 2021

Glucagon

Synthetic

1-29

ssNMR

N/A

6nzn

Gelenter et al., 2019

Glucagon

Synthetic

1-29

cryoEM

3.90

7xm8

Jeong et al., 2022 biorxiv

HET-s (218-289)

recombinant

224-283

ssNMR

N/A

2rnm

Wasmer et al., 2008

hnRNPA1 (186-320)

recombinant

251-295

cryoEM

2.8

7bx7

Sun et al., 2020

hnRNPA1, full-length

Human, recombinant

251-295

cryoEM

3.32

7zj2

Sharma et al., 2023

hnRNPA2

recombinant

263-319

cryoEM

3.1

6wqk

Lu et al., 2020

hnRNPA2 D290V mutation

Human, recombinant, fibril polymorph PM1

263-316

cryoEM

3.30

8du2

Lu et al., 2023

hnRNPA2 D290V mutation

Human, recombinant, fibril polymorph PM2

263-316

cryoEM

3.20

8duw

Lu et al., 2023

hnRNPA2 D290V mutation

Human, recombinant, fibril polymorph PM3

263-313

cryoEM

3.90

8ec7

Lu et al., 2023

hnRNPDL-2

recombinant

345-395

cryoEM

2.50

7zir

Garcia-Pardo et al., 2023

insulin

Human, recombinant, pH 2, fibril type II

A2-20, B5-19

cryoEM

3.20

8sbd

Wang et al., 2023

Islet Amyloid Polypeptide (IAPP), human, SUMO-tagged

recombinant

14-37

cryoEM

3.7

6vw2

Cao et al., 2020

Islet Amyloid Polypeptide (IAPP), amidated C-term, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 2

6-37

cryoEM

3.9

7m62

Cao et al., 2021

Islet Amyloid Polypeptide (IAPP), amidated C-term, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 3

13-37

cryoEM

4.0

7m64

Cao et al., 2021

Islet Amyloid Polypeptide (IAPP) amidated C-term

Human, synthetic

13-37

cryoEM

4.2

6y1a

Röder et al., 2020

Islet Amyloid Polypeptide (IAPP) amidated C-term

Synthetic

13-37

cryoEM

3.6

6zrf

Gallardo et al., 2020

Islet Amyloid Polypeptide (IAPP), amidated C-term, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 1

13-37

cryoEM

3.8

7m61

Cao et al., 2021

Islet Amyloid Polypeptide (IAPP) amidated C-term S20G mutant

Synthetic

15-37

cryoEM

3.9

6zrq

Gallardo et al., 2020

Islet Amyloid Polypeptide (IAPP) amidated C-term S20G mutant

Synthetic

15-37

cryoEM

4.0

6zrr

Gallardo et al., 2020

Islet Amyloid Polypeptide (IAPP), amidated C-term, wild type

Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 4

6-37

cryoEM

4.1

7m65

Cao et al., 2021

Islet Amyloid Polypeptide (IAPP), amidated C-term, wild type

Synthetic, no salt, slim form (SF)

11-37

cryoEM

3.6

7ykw

Li et al., 2022

Islet Amyloid Polypeptide (IAPP), amidated C-term, wild type

Synthetic, no salt, thick form type 1 (TF1)

1-37

cryoEM

3.2

7yl3

Li et al., 2022

Islet Amyloid Polypeptide (IAPP), amidated C-term, wild type

Synthetic, no salt, thick form type 2 (TF2)

1-37

cryoEM

3.2

7yl0

Li et al., 2022

Islet Amyloid Polypeptide (IAPP), amidated C-term, wild type

Synthetic, no salt, thick form type 3 (TF3)

1-37

cryoEM

3.3

7yl7

Li et al., 2022

LECT2, human

Recombinant

55-74

cryoEM

2.72

8g2v

Richards et al., 2023

Light Chain λ1, Antibody, human

Extracted from heart of a patient with cardiac AL amyloidosis

15-105

cryoEM

4.0

6ic3

Radamaker et al., 2019

Light Chain λ1, Antibody, human

Extracted from heart of a patient with systemic AL amyloidosis

9-52, 68-108

cryoEM

3.1

7nsl

Radamaker et al., 2021

Light Chain λ3, Antibody, human

Extracted from heart of a patient with cardiac AL amyloidosis, conformation A

9-49, 60-107

cryoEM

3.2

6z1o

Radamaker et al., 2021

Light Chain λ3, Antibody, human

Extracted from heart of a patient with cardiac AL amyloidosis, conformation B

9-49, 68-107

cryoEM

3.4

6z1i

Radamaker et al., 2021

Light Chain λ6, Antibody, human

Extracted from heart of a patient with amyloid cardiomyopathy

1-37, 66-105

cryoEM

3.3

6hud

Swuec et al., 2019

Light Chain λ6, Antibody, human

Extracted from kidney of a patient with AL amyloidosis

1-37, 66-105

cryoEM

4.0

8cpe

Puri et al., 2023

Nup98

Human, recombinant, polymorph 1

85-124

cryoEM

2.76

7q64

Ibáñez de Opakua et al., 2022

Nup98

Human, recombinant, polymorph 2

85-124

cryoEM

3.32

7q65

Ibáñez de Opakua et al., 2022

Nup98

Human, recombinant, polymorph 3

85-121

cryoEM

2.79

7q66

Ibáñez de Opakua et al., 2022

Nup98

Human, recombinant, polymorph 4

87-119

cryoEM

3.37

7q67

Ibáñez de Opakua et al., 2022

Orb2, Drosophila

Extracted from Drosophila brain

176-206

cryoEM

2.6

6vps

Hervás et al., 2020

Prion Protein, human

recombinant

106-145

cryoEM

3.5

6uur

Glynn et al., 2020

Prion Protein, human, V129, F198S

Extracted from patient with Gerstmann-Sträussler-Scheinker disease, type I filament

80-141

cryoEM

3.29

7umq

Hallinan et al., 2022

Prion Protein, human, V129, F198S

Extracted from patient with Gerstmann-Sträussler-Scheinker disease, type IIb filament

80-141

cryoEM

3.13

7un5

Hallinan et al., 2022

Prion Protein, human

recombinant

170-229

cryoEM

2.7

6lni

Wang et al., 2020

Prion Protein, human, E196K Inherited Mutation

recombinant

175-217

cryoEM

3.07

7dwv

Wang et al., 2021

Prion Protein, mouse, PrP23-144

recombinant, polymorph 1

108-141

cryoEM

3.92

8dja

Li et al., 2022

Prion Protein, human, Y145Stop mutation

recombinant

108-141

cryoEM

2.86

7rl4

Li et al., 2022

Prion Protein, Syrian hamster

recombinant, prepared in acidic solution

119-143

cryoEM

2.20

7yat

Chen et al., 2022

Prion Protein, Syrian hamster, infectious, 263K strain

Extracted from clinically ill hamster brain

95-227

cryoEM

3.14

7lna

Kraus et al., 2021

Prion Protein, mouse, anchorless, aRML prion strain, infectious

Extracted from brains of terminally ill mice

93-230

cryoEM

3.00

7td6

Hoyt et al., 2022

Prion Protein, mouse, anchorless, aRML prion strain, infectious

Extracted from brains of terminally ill mice

94-225

cryoEM

2.70

7qig

Manka et al., 2022

Prion Protein, mouse, a22L prion strain, infectious

Extracted from brains of terminally ill mice

94-226

cryoEM

3.20

8efu

Hoyt et al., 2022

Prion Protein, mouse, ME7 prion strain, infectious

Extracted from brains of terminally ill mice

94-229

cryoEM

2.60

8a00

Manka et al., 2023

RIPK1(496-583) + RIPK3(388-518), human

recombinant

448-462, 532-549

ssNMR

N/A

5v7z

Mompeán et al., 2018

RIPK3(388-518) human

recombinant

448-469

cryoEM

4.24

7da4

Wu et al., 2021

RIPK1(516-539)

mouse, recombinant

516-539

ssNMR

N/A

8ib0

Liu et al., 2023 unpublished

RIPK3(418-518) human

recombinant

447-475

ssNMR

N/A

7dac

Wu et al., 2021

Serum Amyloid A, mouse

Extracted from spleen of a mouse with systemic AA amyloidosis, morphology I

1-69

cryoEM

3.0

6dso

Liberta et al., 2019

Serum Amyloid A, mouse

recombinant, seeded by ex vivo fibrils from mouse liver, morphology I

1-69

cryoEM

2.69

7ovt

Heerde et al., 2022

Serum Amyloid A, mouse

Extracted from spleen of a mouse with systemic AA amyloidosis, morphology II

1-69

cryoEM

3.5

6zch

Bansal et al., 2021

Serum Amyloid A, mouse

recombinant, unseeded, in vitro morphology i

1-37

cryoEM

2.73

6zcf

Bansal et al., 2021

Serum Amyloid A, mouse

recombinant, unseeded, in vitro morphology ii

1-37

cryoEM

2.95

6zcg

Bansal et al., 2021

Serum Amyloid A, human

Extracted from kidney of a human with AA amyloidosis, glomerular variant

2-55

cryoEM

2.7

6mst

Liberta et al., 2019

Serum Amyloid A, human

Extracted from kidney of a human with AA amyloidosis, vascular variant

2-69

cryoEM

2.56

7zky

Banerjee et al., 2022

Serum Amyloid A, feline

Extracted from kidney of a domestic short hair cat with AA amyloidosis

19-94

cryoEM

3.30

7zh7

Schulte et al., 2022

SH3 Domain of PI3-kinase

recombinant

1-77

cryoEM

3.4

6r4r

Röder et al., 2019

Superoxide Dismutase

recombinant, full-length

3-55, 86-153

cryoEM

2.95

7vzf

Wang et al., 2022

TAF15

Human, extracted from FTLD-FET patient brain

7-99

cryoEM

1.97

8ons

Tetter et al., 2023

Tau(297-391) First Intermediate Amyloid (FIA) on Pathway to AD and CTE folds

Recombinant

302-316

cryoEM

2.0

8ppo

Lövestam et al., 2024

Tau 3R+4R, Alzheimer's, Paired Helical Filament

Human, extracted from Alzheimers Disease Patient brain

306-378

cryoEM

3.4

5o3l

Fitzpatrick et al., 2017

Tau 3R+4R Paired Helical Filament

Human, extracted Alzheimers Disease Patient brain, supernatant fraction

306-379

cryoEM

3.10

8azu

Stern et al., 2023

Tau 3R+4R Paired Helical Filament

Human, extracted Alzheimers Disease Patient brain, extracellular vesicle fraction

305-379

cryoEM

3.16

8bgs

Fowler et al., 2023 Biorxiv

Tau 3R+4R Paired Helical Filament

Human, extracted Alzheimers Disease Patient brain, cellular fraction

305-379

cryoEM

3.27

8bgv

Fowler et al., 2023 Biorxiv

Tau 3R+4R Paired Helical Filament

Human, extracted Alzheimers Disease Patient brain and Stained with PET ligand APN1607

304-380

cryoEM

3.00

7nrv

Shi et al., 2021

Tau 3R+4R Paired Helical Filament

Human, extracted Alzheimers Disease Patient brain and Stained with PET ligand GTP-1

306-378

cryoEM

2.70

8fug

Merz et al., 2023

Tau 3R+4R Paired Helical Filament

Human, extracted from Alzheimers Disease Patient brain and Soaked with EGCG for 0 hours

304-379

cryoEM

3.40

7upe

Seidler et al., 2022

Tau 3R+4R Paired Helical Filament

Human, extracted from Alzheimers Disease Patient brain and Soaked with EGCG for 1 hour

306-379

cryoEM

3.30

7upf

Seidler et al., 2022

Tau 3R+4R Paired Helical Filament

Human, extracted from Alzheimers Disease Patient brain and Soaked with EGCG for 3 hours

306-379

cryoEM

3.80

7upg

Seidler et al., 2022

Tau 3R+4R Paired Helical Filament

Human, extracted from PrP Cerebral Amyloid Angiopathy Patient Brain

306-378

cryoEM

3.00

7mkf

Hallinan et al., 2021

Tau 3R+4R Paired Helical Filament

Human, extracted from Gerstmann-Sträussler-Scheinker Patient Brain

305-379

cryoEM

3.30

7mkh

Hallinan et al., 2021

Tau 3R+4R Paired Helical Filament

Human, extracted from Primary Age-Related Tauopathy Patient Brain Case 3

304-380

cryoEM

2.76

7nrq

Shi et al., 2021

Tau (297-391)

Human, recombinant, PHF-like polymorph, 200 mM MgCl2, 200 rpm, filament type 4a

304-379

cryoEM

3.20

7ql4

Lövestam et al., 2022

Tau (266-391) and 3R/(297-391)

recombinant, PHF-like polymorph

304-379

cryoEM

3.46

7ymn

Li et al., 2022

Tau(297-391)

Human, recombinant, PHF, long crossover, with AD fold

304-379

cryoEM

2.95

8q8m

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, PHF with AD fold

304-379

cryoEM

2.10

8q8r

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Triple Helical Filament, THF with AD fold

304-379

cryoEM

2.68

8q8s

Lövestam et al., 2024

Tau (297-391)

recombinant, AD-like fold, LiCl, filament type 2c

304-378

cryoEM

3.29

7qjv

Lövestam et al., 2022

Tau 3R+4R, Alzheimer's, Straight Filament

Extracted from brain of a human with Alzheimer's Disease

306-378

cryoEM

3.4

5o3t

Fitzpatrick et al., 2017

Tau 3R+4R Straight Filament

Extracted from Alzheimers Patient Brain and Stained with PET ligand APN1607

304-380

cryoEM

3.55

7nrx

Shi et al., 2021

Tau 3R+4R Straight Filament

Extracted from PrP Cerebral Amyloid Angiopathy Patient Brain

306-378

cryoEM

3.07

7mkg

Hallinan et al., 2021

Tau 3R+4R Straight Filament Conformation 1

Extracted from Primary Age-Related Tauopathy Patient Brain Case 3

304-380

cryoEM

2.68

7nrs

Shi et al., 2021

Tau 3R+4R Straight Filament Conformation 2

Extracted from Primary Age-Related Tauopathy Patient Brain Case 3

304-380

cryoEM

2.68

7nrt

Shi et al., 2021

Tau (297-408) S396D, S400D, T403D

recombinant, filament type 42a

304-379

cryoEM

3.13

7qki

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to AD fold, AD-LIA2

304-379

cryoEM

2.95

8q88

Lövestam et al., 2024

Tau (258-391)

recombinant, phosphoglycerate, 700rpm, filament type 39a

304-379

cryoEM

2.80

7qkk

Lövestam et al., 2022

Tau 3R

Extracted from human SH-SY5Y cell culture, seeded with brain of a patient with Alzheimers Disease

273-274,306-380

cryoEM

2.5

8ore

Tarutani et al., 2023

Tau (266-391)(297-391)

recombinant, MgCl2 and NaCl, filament type 14a

304-379

cryoEM

2.57

7qku

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to AD fold, AD-LIA6

304-379

cryoEM

3.04

8q8d

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to AD fold, AD-LIA7

304-379

cryoEM

3.04

8q8l

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to AD fold, AD-LIA5

304-379

cryoEM

2.93

8q8f

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA11

303-379

cryoEM

3.04

8q9a

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to AD fold, AD-MIA2

303-380

cryoEM

2.23

8q2j

Lövestam et al., 2024

Tau 4R

Extracted from brain of a patient with Chronic Traumatic Encephalopathy, filament type I (CTE-I)

305-379

cryoEM

2.3

6nwp

Falcon et al., 2019

Tau 4R

Extracted from brain of a patient with Chronic Traumatic Encephalopathy, filament type I (CTE-I), complex with PET ligand flortaucipir

305-379

cryoEM

2.6

8byn

Shi et al., 2022

Tau(297-391)

Human, recombinant, CTE fold type I (CTE-I)

305-379

cryoEM

2.65

8q9m

Lövestam et al., 2024

Tau 4R

Extracted from brain of a patient with Chronic Traumatic Encephalopathy, filament type II (CTE-II)

305-379

cryoEM

3.4

6nwq

Falcon et al., 2019

Tau (297-391)

Human, recombinant, filament type 8a, CTE-II-like

305-379

cryoEM

2.81

7qjw

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, CTE fold type II (CTE-II-like)

305-379

cryoEM

3.10

8q9o

Lövestam et al., 2024

Tau (266-391)(297-391)

recombinant, CTE-like fold, MgSO4, NaCl, filament type 15b

306-378

cryoEM

3.16

7qkx

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to CTE fold, CTE-LIA4

306-378

cryoEM

2.18

8q9h

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to CTE fold, CTE-LIA13

306-379

cryoEM

3.20

8q9k

Lövestam et al., 2024

Tau (266-391)(297-391)

recombinant, CTE-like fold, MgSO4, NaCl, filament type 15c

306-377

cryoEM

3.13

7ql0

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to CTE fold, CTE-LIA3

305-379

cryoEM

1.91

8q9f

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to CTE fold, CTE-LIA5

306-378

cryoEM

2.65

8q9g

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to CTE fold, CTE-LIA7

306-378

cryoEM

2.96

8q9j

Lövestam et al., 2024

Tau (266-391)(297-391)

recombinant, CTE-like fold, MgSO4, NaCl, filament type 15a

309-377

cryoEM

3.23

7qkv

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to CTE fold, CTE-LIA14

306-378

cryoEM

2.76

8q9l

Lövestam et al., 2024

Tau (266-391)

recombinant, CTE-like fold, phosphate-buffered saline, filament type 23a

306-378

cryoEM

3.34

7ql1

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to CTE fold, CTE-LIA6

306-378

cryoEM

2.56

8q9i

Lövestam et al., 2024

Tau (266-391)(297-391)

recombinant, LiCl, filament type 9b

305-378

cryoEM

3.40

7qjz

Lövestam et al., 2022

Tau (266-391)(297-391)

recombinant, KCl, filament type 10b

305-388

cryoEM

2.59

7r5h

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to AD fold, AD-MIA1

303-379

cryoEM

2.02

8q27

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to AD fold, AD-MIA10

304-378

cryoEM

1.92

8q8c

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to AD fold, AD-MIA6

306-379

cryoEM

2.82

8q7l

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to AD fold, AD-MIA7

304-379

cryoEM

3.26

8q7m

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to AD fold, AD-LIA4

304-379

cryoEM

3.81

8q8e

Lövestam et al., 2024

Tau (266-391)(297-391)

recombinant, KCl, filament type 10a

306-379

cryoEM

1.92

7qk5

Lövestam et al., 2022

Tau (297-394)

recombinant, phosphate buffered saline, filament type 35d

305-379

cryoEM

3.03

7qk1

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Late Intermediate Amyloid on Pathway to AD fold, AD-LIA8

304-379

cryoEM

3.21

8qcp

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA12

305-379

cryoEM

2.75

8qcr

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA14

305-379

cryoEM

3.40

8q9c

Lövestam et al., 2024

Tau (300-391)

recombinant, phosphate buffered saline, filament type 36a

308-378

cryoEM

2.61

7qk2

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA4

304-378

cryoEM

2.85

8q8w

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA7

305-379

cryoEM

3.16

8q8z

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA5

303-379

cryoEM

2.54

8q8x

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA6

306-379

cryoEM

2.88

8q8y

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to AD fold, AD-MIA11

304-378

cryoEM

3.00

8q7t

Lövestam et al., 2024

Tau (266-391)(297-391)

recombinant, MgCl2, NaCl, filament type 14b

305-379

cryoEM

3.26

7qkj

Lövestam et al., 2022

Tau (266-391)(297-391)

recombinant, NaCl, filament type 8b

308-378

cryoEM

3.32

7ql3

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to AD fold, AD-MIA5

304-378

cryoEM

3.72

8q7f

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA18

308-379

cryoEM

2.97

8q9e

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA10

308-378

cryoEM

2.70

8q99

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA1

308-378

cryoEM

3.30

8q8u

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to AD fold, AD-MIA8

304-378

cryoEM

3.28

8q7p

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA3

305-379

cryoEM

3.80

8q8v

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA13

305-379

cryoEM

3.10

8q9b

Lövestam et al., 2024

Tau (266-391)+(297-391)

recombinant, NaHCO3, NaCl, filament type 16a

304-379

cryoEM

2.75

7r4t

Lövestam et al., 2022

Tau (266-391)(297-391)

recombinant, LiCl, filament type 9a

305-379

cryoEM

3.14

7qjy

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA6

308-378

cryoEM

2.99

8q97

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA8

305-379

cryoEM

1.75

8q98

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to AD fold, AD-MIA3

305-379

cryoEM

2.88

8q2k

Lövestam et al., 2024

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to CTE fold, CTE-MIA15

305-379

cryoEM

3.16

8q9d

Lövestam et al., 2024

Tau (266-391)(297-391)

recombinant, ZnCl2, filament type 11a

304-379

cryoEM

2.07

7qkl

Lövestam et al., 2022

Tau(297-391)

Human, recombinant, Middle Intermediate Amyloid on Pathway to AD fold, AD-MIA4

307-378

cryoEM

2.20

8q2l

Lövestam et al., 2024

Tau (297-391)

recombinant, 700 rpm, filament type 34b

304-378

cryoEM

2.99

7qjx

Lövestam et al., 2022

Tau 3R

Extracted from brain of a human with Pick's Disease

254-274, 306-378

cryoEM

3.2

6gx5

Falcon et al., 2018

Tau 3R ΔK281 mutation

Extracted from brain of a human with Pick's Disease and MAPT ΔK281 mutation

254-274, 306-378

cryoEM

2.61

8p34

Schweighauser et al., 2023

Tau (297-391)

recombinant, spindle-like fold

304-362

cryoEM

2.54

7ypg

Li et al., 2022

Tau 4R

Extracted from brain of a human with Corticobasal Degeneration (CBD), Filament Type I

274-380

cryoEM

3.2

6tjo

Zhang et al., 2020

Tau 4R

Extracted from Argyrophilic Grain Disease (AGD) Patient Brain, Filament Type 1

273-387

cryoEM

3.30

7p6d

Shi et al., 2021

Tau 4R

Extracted from human SH-SY5Y cell culture, seeded with brain of a patient with Corticobasal Degeneration (CBD), Filament Type I

277-377

cryoEM

2.5

8orf

Tarutani et al., 2023

Tau 4R

Extracted from human SH-SY5Y cell culture, seeded with brain of a patient with Corticobasal Degeneration (CBD), Filament Type II

277-362

cryoEM

2.3

8org

Tarutani et al., 2023

Tau 4R

Extracted from brain of a human with Corticobasal Degeneration (CBD), Filament Type II

274-380

cryoEM

3.0

6tjx

Zhang et al., 2020

Tau 4R

Extracted from Argyrophilic Grain Disease (AGD) Patient Brain, Filament Type 2

274-381

cryoEM

3.40

7p6e

Shi et al., 2021

Tau (198-399)

Human, recombinant, observed at 24° C

274-325

ssNMR

N/A

8g54

El Mammeri et al., 2023

Tau (198-399)

Human, recombinant, observed at 12° C

264-326

ssNMR

N/A

8g55

El Mammeri et al., 2023

Tau 4R

Extracted from Progressive Supranuclear Palsy (PSP) Patient Brain

272-381

cryoEM

2.70

7p65

Shi et al., 2021

Tau 4R

Extracted from Progressive Supranuclear Palsy (PSP) Patient Brain, Case 1

272-381

cryoEM

4.20

7u0z

Chang et al., 2022

Tau 4R

Extracted from Globular Glial Tauopathy (GGT) Patient Brain, Filament Type 1

272-379

cryoEM

3.00

7p66

Shi et al., 2021

Tau 4R

Extracted from Globular Glial Tauopathy (GGT) Patient Brain, filament type 2

272-379

cryoEM

3.10

7p67

Shi et al., 2021

Tau 4R

Extracted from Globular Glial Tauopathy (GGT) Patient Brain, Filament Type 3

272-379

cryoEM

2.90

7p68

Shi et al., 2021

Tau 4R

Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy (LNT) Patient Brain, Filament Type 1a

272-379

cryoEM

1.90

7p6a

Shi et al., 2021

Tau 4R

Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy (LNT) Patient Brain, Filament Type 1b

272-379

cryoEM

2.50

7p6b

Shi et al., 2021

Tau 4R

Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy (LNT) Patient Brain, Filament Type 2

272-379

cryoEM

2.20

7p6c

Shi et al., 2021

Tau 4R P301S mutation

Human, extracted from transgenic mouse line PS19 brain

271-364

cryoEM

3.05

8q92

Schweighauser et al., 2023

Tau 4R P301S mutation

Human, extracted from transgenic mouse line TG2541 brain

249-345

cryoEM

3.09

8q96

Schweighauser et al., 2023

Tau40 and RNA

recombinant and grown with RNA

391-426

cryoEM

3.40

7sp1

Abskharon et al., 2022

Tau 0N4R with phosphoserine

recombinant, filament type 47a

376-441

cryoEM

1.86

7qky

Lövestam et al., 2022

Tau (266-391)(297-391)

recombinant, CuCl2, filament type 12a

309-360, 305-335

cryoEM

2.83

7qkf

Lövestam et al., 2022

Tau 4R

recombinant, Heparin Induced, Snake Polymorph

272-330

cryoEM

3.3

6qjh

Zhang et al., 2019

Tau 4R

recombinant, Heparin Induced, Twister Polymorph

274-292, 304-321

cryoEM

3.3

6qjm

Zhang et al., 2019

Tau 4R

recombinant, Heparin Induced, Jagged Polymorph

274-290, 304-321

cryoEM

3.5

6qjp

Zhang et al., 2019

Tau (258-391)

recombinant, heparan sulfate, 700 rpm, filament type 40a

275-328

cryoEM

2.27

7qk6

Lövestam et al., 2022

Tau (258-391)

recombinant, phosphoglycerate, 700 rpm, filament type 39a

275-328

cryoEM

3.36

7qkg

Lövestam et al., 2022

Tau (266-391) S356D

recombinant, KCl, filament type 44a

275-328

cryoEM

2.32

7qkw

Lövestam et al., 2022

Tau (244-391)

recombinant, Na4P2O7, filament type 20a

275-324

cryoEM

2.95

7ql2

Lövestam et al., 2022

Tau (258-391)

recombinant, 700 rpm, filament type 38a

270-330

cryoEM

2.44

7qk3

Lövestam et al., 2022

Tau (266-391) S356D

recombinant, NaCl, filament type 45a

274-328

cryoEM

2.66

7qkm

Lövestam et al., 2022

Tau 3R

recombinant, Heparin Induced

272-274,306-330

cryoEM

3.5

6qjq

Zhang et al., 2019

Tau (258-391)

recombinant, sodium azide, filament type 41a

277-317

cryoEM

3.17

7qkh

Lövestam et al., 2022

Tau (305-379)

recombinant, filament type 27a

307-317

cryoEM

2.65

7qkz

Lövestam et al., 2022

Tau (263-280), acetylated K274 and K280

human, synthetic

263-280

cryoEM

3.88

8fnz

Li et al., 2023

TDP-43

Human, synthetic, residues 247-257

247-257

cryoEM

3.7

5w7v

Guenther et al., 2018

TDP-43

Human, recombinant, residues 311-360

312-347

cryoEM

3.8

6n37

Cao et al., 2019

TDP-43

Human, recombinant, residues 311-360

312-352

cryoEM

3.8

6n3b

Cao et al., 2019

TDP-43

Human, recombinant, residues 311-360

311-360

cryoEM

3.3

6n3a

Cao et al., 2019

TDP-43

Human, recombinant, A315E mutation, residues 286-331

288-319

cryoEM

3.3

6n3c

Cao et al., 2019

TDP-43

Human, recombinant, Low Complexity Domain, residues 267-414

276-414

cryoEM

3.2

7kwz

Li et al., 2021

TDP-43

Human, recombinant, full-length, morphology 1a

304-348

cryoEM

3.76

8qx9

Sharma et al., 2024

TDP-43

Human, recombinant, full-length, morphology 1b

304-348

cryoEM

4.05

8qxa

Sharma et al., 2024

TDP-43

Human, recombinant, full-length, morphology 2

304-348

cryoEM

3.86

8qxb

Sharma et al., 2024

TDP-43

Human, extracted from Patient with Amyotrophic Lateral Sclerosis and Fronto-temporal Lobar Degeneration type B

282-360

cryoEM

2.59

7py2

Arseni et al., 2021

TDP-43

Human, extracted from Patient with Fronto-temporal Lobar Degeneration type A, filament block variant 1

272-360

cryoEM

2.39

8cg3

Arseni et al., 2023

TDP-43

Human, extracted from Patient with Fronto-temporal Lobar Degeneration type A, filament block variant 2

281-360

cryoEM

2.50

8cgg

Arseni et al., 2023

TDP-43

Human, extracted from Patient with Fronto-temporal Lobar Degeneration type A, filament block variant 3

281-360

cryoEM

2.68

8cgh

Arseni et al., 2023

TDP-43

Human, recombinant, residues 279-360 singlet fibril

281-351

cryoEM

3.70

7q3u

Kumar et al., 2023

TFG (237-327) G269V

Recombinant, human, G269V mutation, low complexity domain (237-327)

262-290

cryoEM

2.84

8teq

Rosenberg et al., 2023

TFG (237-327) P285L

Recombinant, human, P285L mutation, low complexity domain (237-327)

265-299

cryoEM

2.59

8ter

Rosenberg et al., 2023

TMEM106B Polymorph 1

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type C

120-254

cryoEM

2.90

7saq

Jiang et al., 2022

TMEM106B Fold I

Extracted from Patient with Alzheimer's Disease, case 1

120-254

cryoEM

2.64

7qvc

Schweighauser et al., 2022

TMEM106B Fold II-a

Extracted from Patient with Multiple System Atrophy, case 19

120-254

cryoEM

3.38

7qwg

Schweighauser et al., 2022

TMEM106B Fold II-b

Extracted from Patient with Multiple System Atrophy, case 19

120-254

cryoEM

3.47

7qwl

Schweighauser et al., 2022

TMEM106B Fold III

Extracted from Patient with Multiple System Atrophy, case 17

120-254

cryoEM

2.76

7qwm

Schweighauser et al., 2022

TMEM106B singlet filament

Extracted from Patient with Progressive Supranuclear Palsy, case 2

120-254

cryoEM

3.00

7u10

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type A, case 1

120-254

cryoEM

3.20

7u11

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type A, case 2

120-254

cryoEM

3.50

7u12

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type A, case 4

120-254

cryoEM

2.90

7u13

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type C, case 8

120-254

cryoEM

4.50

7u14

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type B, case 7

120-254

cryoEM

3.00

7u15

Chang et al., 2022

TMEM106B singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type A, all cases combined

120-254

cryoEM

2.70

7u16

Chang et al., 2022

TMEM106B T185S singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type B, all cases combined

120-254

cryoEM

3.00

7u17

Chang et al., 2022

TMEM106B T185S singlet filament

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type A, all cases combined

120-254

cryoEM

2.70

7u18

Chang et al., 2022

TMEM106B

Extracted from brain of 101 year old human with no diagnosed disease

120-254

cryoEM

3.40

7x83

Fan et al., 2022

TMEM106B

Extracted from brain of patient with Parkinsons Disease Dementia

120-254

cryoEM

3.00

7x84

Fan et al., 2022

TMEM106B Polymorph 2

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type C

120-254

cryoEM

3.20

7sar

Jiang et al., 2022

TMEM106B Fold I-d

Extracted from Patient with Multiple System Atrophy, case 18

120-254

cryoEM

3.64

7qvf

Schweighauser et al., 2022

TMEM106B Polymorph 3

Extracted from Patient with Fronto-temporal Lobar Degeneration, Type C

120-254

cryoEM

3.70

7sas

Jiang et al., 2022

Transforming Growth Factor Beta Induced Protein, TGFBIp(611-633), G623R

Human, recombinant

1-23

cryoEM

4.90

8hia

Low et al., 2023

Transthyretin, V30M

Human, V30M mutation, extracted from the Vitreous Body of the Eye of an Amyloid Transthyretin Amyloidosis (ATTR) Patient

11-35, 57-123

cryoEM

3.22

7ob4

Iakovleva et al., 2021

Transthyretin, V30M

Human, V30M mutation, extracted from heart of a patient with hereditary V30M ATTR Amyloidosis

11-35, 57-123

cryoEM

3.0

6sdz

Schmidt et al., 2019

Transthyretin

Human, wild type, extracted from the heart a Senile Systemic Amyloidosis Patient

11-35, 57-123

cryoEM

2.78

8ade

Steinebrei et al., 2022

Transthyretin

Human, wild type, extracted from the heart a Senile Systemic Amyloidosis Patient

11-35, 57-123

cryoEM

2.78

7z40

Steinebrei et al., 2022

Transthyretin

Human, wild type, extracted from the heart a Transthyretin Amyloidosis Patient

11-34, 58-123

cryoEM

3.31

8e7d

Nguyen et al., 2023 Biorxiv

Transthyretin

Human, wild type, extracted from the heart a Transthyretin Amyloidosis Patient

12-35, 58-123

cryoEM

3.70

8e7h

Nguyen et al., 2023 Biorxiv

Transthyretin, P24S

Human, P24S mutation, extracted from the heart a Transthyretin Amyloidosis Patient

12-34, 58-123

cryoEM

3.65

8e7i

Nguyen et al., 2023 Biorxiv

Transthyretin, I84S

Human, I84S mutation, extracted from the heart a Transthyretin Amyloidosis Patient

12-35, 64-122

cryoEM

3.10

8e7j

Nguyen et al., 2023 Biorxiv

Transthyretin, I84S

Human, I84S mutation, extracted from the heart a Transthyretin Amyloidosis Patient

14-32, 67-122

cryoEM

3.61

8e7e

Nguyen et al., 2023 Biorxiv