Amyloid Fibril Models

coordinates and illustrations

Jacques Philippe Colletier, Arthur Laganowsky, Angela Soriaga, Minglei Zhao, Meytal Landau, Lukasz Goldschmidt, David Flot, Duilio Cascio, Kanagalaghatta Rajashankar, Igor Kourinov, Shilpa Sambahivan, Rebecca Nelson, Magdalena Ivanova, Michael R. Sawaya, Stuart Sievers, Michael J. Thompson, Melinda Balbirnie, Marcin Apostol, Jed Wiltzius, Heather McFarlane, Anders O. Madsen, Christian Riekel, David Eisenberg.

protein	3D interactive demo (jmol) or static image	coordinates			movie/reference
Alpha-synuclein (residues 42-83, with a homotypic interface compsed of residues 65-80)			partial pitch length		Structure of the toxic core of α-synuclein from invisible crystals Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. Nature. 2015 Sep 24;525(7570):486-90.
Amyloid-Beta (residues 9-42, with a homotypic interface compsed of residues 30-42)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (residues 9-42, Iowa mutant)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (residues 11-25)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (residues 16-35)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (residues 22-35)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (residues 30-42)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (Riek hairpin with interface at residues 16-21)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (Riek hairpin with interface at residues 35-42)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (Tycko hairpin with interfaces at residues 16-21 and 27-32)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (Tycko hairpin with interfaces at residues 16-21 and 35-42)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (Tycko hairpin with interfaces at residues 27-32 and 16-21)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (Tycko hairpin with interfaces at residues 27-32 and 35-42)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (Tycko hairpin with interfaces at residues 35-42 and 16-21)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (Tycko hairpin with interfaces at residues 35-42 and 27-32)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (Tycko hairpin with interfaces at residues 16-21)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (Tycko hairpin with an interface at residues 27-32)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Amyloid-Beta (Tycko hairpin with an interface at residues 35-42)			partial pitch length		Molecular basis for amyloid-beta polymorphism. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
Insulin (human)		asymmetric unit	partial pitch length	full pitch length	morph between globular and fibrilar insulin
Islet Amyloid Polypeptide (human)		asymmetric unit	partial pitch length		Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Wiltzius JJ, Sievers SA, Sawaya MR, Cascio D, Popov D, Riekel C, Eisenberg D. Protein Sci. 2008 Sep;17(9):1467-74
RNase (bovine, engineered)		asymmetric unit	partial pitch length	full pitch length	Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure. Sambashivan S, Liu Y, Sawaya MR, Gingery M, Eisenberg D. Nature. 2005 Sep 8;437(7056):266-9.
beta2 microglobulin (human)		asymmetric unit	partial pitch length	full pitch length plus	An amyloid-forming segment of beta2-microglobulin suggests a molecular model for the fibril. Ivanova MI, Sawaya MR, Gingery M, Attinger A, Eisenberg D. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10584-9.
Prion Protein (human)		asymmetric unit	partial pitch length	full pitch length	Seeded conversion of recombinant prion protein to a disulfide-bonded oligomer by a reduction-oxidation process. Lee S, Eisenberg D. Nat Struct Biol. 2003 Sep;10(9):725-30.